Wang Junwen, Bai Lin, Ye Yuyang, Chen Xuefeng, Hu Xinru, Peng Yong
Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China.
Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China.
Exp Gerontol. 2024 Dec;198:112643. doi: 10.1016/j.exger.2024.112643. Epub 2024 Nov 28.
It remains unclear whether there are sex differences in the correlation between klotho and mortality risk. The purpose of our study is to investigate the relationship between klotho levels and all-cause mortality, specifically examining potential sex disparities.
The study utilized data from the National Health and Nutrition Examination Survey. The study employed the Cox proportional hazards model and Kaplan-Meier survival curves to conduct multivariate analyses investigating the associations between klotho and mortality. The impact of klotho level on mortality was assessed by a restricted cubic spline curve.
Our study included 13,748 participants. The hazard ratios (HR) for all-cause mortality were found to be higher in males compared to females. The risk of all-cause mortality decreased until the klotho level reached 959 pg/mL in all-cause mortality, then increased thereafter in females (P value for nonlinearity = 0.01, P overall = 0.02); no curved relationship was observed in males.
Klotho levels and mortality follow a U-shaped curve, with sex differences in the relationship. Males with higher klotho levels have a higher risk of all-cause death than females.
目前尚不清楚klotho与死亡风险之间的相关性是否存在性别差异。我们研究的目的是调查klotho水平与全因死亡率之间的关系，特别关注潜在的性别差异。
本研究使用了来自美国国家健康与营养检查调查的数据。采用Cox比例风险模型和Kaplan-Meier生存曲线对klotho与死亡率之间的关联进行多变量分析。通过受限立方样条曲线评估klotho水平对死亡率的影响。
我们的研究纳入了13748名参与者。发现男性全因死亡率的风险比（HR）高于女性。在全因死亡率方面，klotho水平达到959 pg/mL之前，全因死亡风险降低，之后在女性中升高（非线性P值 = 0.01，总体P值 = 0.02）；在男性中未观察到曲线关系。
Klotho水平与死亡率呈U形曲线关系，且存在性别差异。klotho水平较高的男性全因死亡风险高于女性。
