Yuan Xuan, Meng Lai, Liu Liyuan, Zhang Benjian, Xie Shaobing, Zhong Wei, Jia Jiaxin, Zhang Hua, Jiang Weihong, Xie Zhihai
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, 87 Xiangya Road, Kaifu District, Changsha, 410008, People's Republic of China.
Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China.
Eur Arch Otorhinolaryngol. 2025 Mar;282(3):1289-1299. doi: 10.1007/s00405-024-09109-7. Epub 2024 Nov 29.
To investigate the associations between fasting blood glucose (FBG) and type 2 diabetes mellitus (T2DM) and the risk of postoperative CRS recurrence.
A retrospective cohort study was conducted on clinical data of CRS patients who underwent surgery at our center between February 2019 and March 2022 and were followed up until June 2023. All CRS patients were categorized into two subgroups based on the presence of T2DM and postoperative recurrence. The Kaplan-Meier survival curves and binary logistic regression analyses were performed to examine the associations between FBG, T2DM, and the risk of postoperative CRS recurrence.
1163 CRS patients were enrolled, including 134 in the T2DM group and 276 in the recurrent group. The recurrence rate in the T2DM group was significantly higher than that in the non-T2DM group (P < 0.05). T2DM prevalence and FBG levels were higher in the recurrent CRS group than in the non-recurrent CRS group (P < 0.05). The Kaplan-Meier survival curves and unadjusted and adjusted logistic regression models showed that T2DM was an independent risk factor for postoperative CRS recurrence (P < 0.05). Moreover, multivariate logistic regression analysis suggested that FBG, CRS duration, and allergic rhinitis were associated with the risk of postoperative CRS recurrence (P < 0.05).
Elevated FBG levels and accompanying T2DM were associated with an increased risk of postoperative CRS recurrence, which was independent of traditional risk factors. CRS duration and accompanying allergic rhinitis were also proven to be potential risk factors for postoperative CRS recurrence.
探讨空腹血糖（FBG）与2型糖尿病（T2DM）之间的关联以及术后慢性鼻-鼻窦炎（CRS）复发风险。
对2019年2月至2022年3月在本中心接受手术并随访至2023年6月的CRS患者的临床资料进行回顾性队列研究。所有CRS患者根据是否存在T2DM和术后复发情况分为两个亚组。采用Kaplan-Meier生存曲线和二元逻辑回归分析来检验FBG、T2DM与术后CRS复发风险之间的关联。
共纳入1163例CRS患者，其中T2DM组134例，复发组276例。T2DM组的复发率显著高于非T2DM组（P＜0.05）。复发的CRS组中T2DM患病率和FBG水平高于未复发的CRS组（P＜0.05）。Kaplan-Meier生存曲线以及未调整和调整后的逻辑回归模型显示，T2DM是术后CRS复发的独立危险因素（P＜0.05）。此外，多因素逻辑回归分析表明，FBG、CRS病程和变应性鼻炎与术后CRS复发风险相关（P＜0.05）。
FBG水平升高及伴发的T2DM与术后CRS复发风险增加相关，且独立于传统危险因素。CRS病程和伴发的变应性鼻炎也被证明是术后CRS复发的潜在危险因素。
