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铁死亡相关长链非编码RNA AL136084.3与膀胱癌中的NUPR1相关。

Ferroptosis-related lncRNA AL136084.3 is associated with NUPR1 in bladder cancer.

作者信息

Zhou Jing, Zhang Li, Wu Hao, Gao Sheng-Lin, Chen Xiao-Ping, Zhang Li-Feng, Zhao Cui-Ping, Wei Bing-Bing, Bai Yu

机构信息

Department of Medical Oncology, Affiliated Hospital of Jiangnan University, Hefeng Road 1000, Wuxi, 214000, China.

Department of Urology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, 68 Gehu Road, Changzhou, 213000, Jiangsu, China.

出版信息

Discov Oncol. 2024 Nov 30;15(1):730. doi: 10.1007/s12672-024-01564-2.

DOI:10.1007/s12672-024-01564-2
PMID:39613992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11607367/
Abstract

BACKGROUND

LncRNAs are critical regulators of bladder cancer (BLCA), and ferroptosis is a newly discovered cell death responsible for mediating apoptosis and tumorigenesis. The present study aims to establish a prognostic signature of differentially expressed ferroptosis-related lncRNAs (DEFRlncRNAs) and explore the DEFRlncRNA associated with NUPR1 in BLCA.

METHODS

DEFRlncRNAs in BLCA patients were screened using univariate and multivariate Cox and LASSO regression analyses. In vitro experiments were performed to detect the regulatory effects of DEFRlncRNAs on BLCA cells. A prognostic signature of DEFRlncRNAs in BLCA was created and validated. Moreover, we used RNA-binding protein immunoprecipitation (RIP) to evaluate the correlated DEFRlncRNA with NUPR1.

RESULTS

A prognostic signature involving 18 DEFRlncRNAs in BLCA was created. Overexpression of AL355353.2 or knockdown of AL136084.3 promoted apoptosis in 5637 and T24 cells in vitro. Results from Starbase database estimated that AL136084.3 was positively associated with NUPR1 (R = 0.229, p < 0.001). RIP analysis revealed the reciprocal binding of NUPR1 and AL136084.3 in BLCA.

CONCLUSION

The identified FRlncRNA pair signature has a good prognostic and clinical predictive value. The ferroptosis-related lncRNA AL136084.3 is correlated with NUPR1 in BLCA.

摘要

背景

长链非编码RNA（lncRNAs）是膀胱癌（BLCA）的关键调节因子，而铁死亡是一种新发现的细胞死亡方式，可介导细胞凋亡和肿瘤发生。本研究旨在建立差异表达的铁死亡相关lncRNAs（DEFRlncRNAs）的预后特征，并探索BLCA中与核仁蛋白1（NUPR1）相关的DEFRlncRNA。

方法

采用单变量和多变量Cox及LASSO回归分析筛选BLCA患者中的DEFRlncRNAs。进行体外实验以检测DEFRlncRNAs对BLCA细胞的调节作用。建立并验证了BLCA中DEFRlncRNAs的预后特征。此外，我们使用RNA结合蛋白免疫沉淀（RIP）来评估与NUPR1相关的DEFRlncRNA。

结果

建立了一个包含18个BLCA中DEFRlncRNAs的预后特征。在体外，过表达AL355353.2或敲低AL136084.3可促进5637和T24细胞凋亡。Starbase数据库结果估计AL136084.3与NUPR1呈正相关（R = 0.229，p < 0.001）。RIP分析揭示了BLCA中NUPR1与AL136084.3的相互结合。

结论

所鉴定的FRlncRNA对特征具有良好的预后和临床预测价值。铁死亡相关lncRNA AL136084.3在BLCA中与NUPR1相关。

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本文引用的文献

1
Mechanistic study of NUPR1 in bladder cancer development through transcriptional regulation of CCR2.通过对 CCR2 的转录调控研究 NUPR1 在膀胱癌发展中的作用机制。
J Cell Physiol. 2024 Nov;239(11):e31412. doi: 10.1002/jcp.31412. Epub 2024 Aug 16.
2
A first-in-class TIMM44 blocker inhibits bladder cancer cell growth.一种一流的TIMM44阻断剂可抑制膀胱癌细胞生长。
Cell Death Dis. 2024 Mar 11;15(3):204. doi: 10.1038/s41419-024-06585-x.
3
Impact of the cytotoxic T-lymphocyte associated antigen-4 rs231775 A/G polymorphism on cancer risk.
细胞毒性T淋巴细胞相关抗原4 rs231775 A/G多态性对癌症风险的影响。
Heliyon. 2023 Dec 3;9(12):e23164. doi: 10.1016/j.heliyon.2023.e23164. eCollection 2023 Dec.
4
Ferroptosis in Cancer Progression.铁死亡在癌症进展中的作用。
Cells. 2023 Jul 10;12(14):1820. doi: 10.3390/cells12141820.
5
Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients.根治性膀胱切除术治疗浸润性膀胱癌：1054 例患者的长期结果。
J Clin Oncol. 2023 Aug 1;41(22):3772-3781. doi: 10.1200/JCO.22.02762.
6
Stimuli-responsive ferroptosis for cancer therapy.刺激响应型铁死亡用于癌症治疗。
Chem Soc Rev. 2023 Jun 19;52(12):3955-3972. doi: 10.1039/d3cs00001j.
7
Expression Is Associated with PPARG in Bladder Transitional Cell Carcinoma.在膀胱移行细胞癌中，表达与PPARG相关。
PPAR Res. 2023 May 8;2023:6797694. doi: 10.1155/2023/6797694. eCollection 2023.
8
Global trends in the epidemiology of bladder cancer: challenges for public health and clinical practice.膀胱癌流行病学的全球趋势：公共卫生和临床实践面临的挑战。
Nat Rev Clin Oncol. 2023 May;20(5):287-304. doi: 10.1038/s41571-023-00744-3. Epub 2023 Mar 13.
9
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.脂质过氧化作用会增加膜张力，开启 Piezo1 通道，并增加阳离子通透性，从而执行铁死亡。
Curr Biol. 2023 Apr 10;33(7):1282-1294.e5. doi: 10.1016/j.cub.2023.02.060. Epub 2023 Mar 9.
10
LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer.LncRNA-BC069792 通过靶向乳腺癌中的 KCNQ4 抑制肿瘤进展。
Mol Cancer. 2023 Mar 1;22(1):41. doi: 10.1186/s12943-023-01747-5.