Wang Ya-Feng, Lin Ping, Pang Nao, Liu Zhang-Bin, Yang Bing-Yuan, He Rui-Jie, Huang Yong-Lin
Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, China.
J Nat Med. 2025 Jan;79(1):258-267. doi: 10.1007/s11418-024-01864-5. Epub 2024 Nov 29.
Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lignan dimer compounds with anti-inflammatory activity and four known compounds were isolated and identified from 80% methanolic extract of Castanopsis chinensis leaves. The structure determination supported by computational chemistry and extensive spectroscopic analysis. Two new lignan dimer compounds significantly inhibited LPS-induced NO production in RAW 264.7 cells at 10 µM without cytotoxicity.
锥属（壳斗科）富含植物多酚，常被用作药用植物。在本研究中，从中国锥叶片的80%甲醇提取物中分离并鉴定出两种具有抗炎活性的新木脂素二聚体化合物和四种已知化合物。通过计算化学和广泛的光谱分析确定了其结构。两种新的木脂素二聚体化合物在10 µM时能显著抑制RAW 264.7细胞中LPS诱导的NO生成，且无细胞毒性。
