School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China.
Fitoterapia. 2022 Sep;161:105244. doi: 10.1016/j.fitote.2022.105244. Epub 2022 Jun 18.
Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway. All monomer compounds exhibited inhibitory effects on NO production in LPS-induced RAW 264.7 cells without affecting cell viabilities, which were comparable to that of positive control.
从中国西南和东部广泛分布的药用植物荆芥中分离得到两种以前未描述的二萜（1 和 2）和一种奇特的三萜。通过 MS 分析、UV 光谱和广泛的 2D-同核和异核 NMR 数据分析阐明了它们的结构。其中，1 具有由罕见的甲基迁移途径产生的不寻常的骨架特征。所有单体化合物均表现出对 LPS 诱导的 RAW 264.7 细胞中 NO 产生的抑制作用，而不影响细胞活力，与阳性对照相当。
