Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Huihe Road 200, Wuxi, Jiangsu, 214062, China.
Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu, 214122, China.
J Exp Clin Cancer Res. 2024 Nov 30;43(1):315. doi: 10.1186/s13046-024-03235-0.
Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since its discovery in 2012, extensive research has demonstrated its pivotal roles in tumorigenesis, metastasis and cancer therapy. The tumor microenvironment (TME) is a complex ecosystem comprising cancer cells, non-cancer cells, extracellular matrix, metabolites and cytokines. Recent studies have underscored a new paradigm in which non-cancer cells in the TME, such as immune and stromal cells, also play significant roles in regulating tumor progression and therapeutic resistance typically through complicated crosstalk with cancer cells. Notably, this crosstalk in the TME were partially mediated through ferrotopsis-related mechanisms. This review provides a comprehensive and systematic summary of the current findings concerning the roles of ferroptosis in the TME and how ferroptosis-mediated TME reprogramming impacts cancer therapeutic resistance and progression. Additionally, this review outlines various ferroptosis-related therapeutic strategies aimed at targeting the TME.
铁死亡是一种受调控的细胞死亡方式，其特征是非凋亡、铁依赖性和氧化性质。自 2012 年发现以来，广泛的研究表明它在肿瘤发生、转移和癌症治疗中具有关键作用。肿瘤微环境（TME）是一个复杂的生态系统，包括癌细胞、非癌细胞、细胞外基质、代谢物和细胞因子。最近的研究强调了一种新的模式，即 TME 中的非癌细胞，如免疫和基质细胞，也通过与癌细胞的复杂相互作用，在调节肿瘤进展和治疗耐药性方面发挥重要作用。值得注意的是，这种 TME 中的串扰部分是通过铁死亡相关机制介导的。本综述全面系统地总结了铁死亡在 TME 中的作用以及铁死亡介导的 TME 重编程如何影响癌症治疗耐药性和进展的最新发现。此外，本综述还概述了各种针对 TME 的铁死亡相关治疗策略。
