Moulin J J, Mur J M, Wild P, Perreaux J P, Pham Q T
Scand J Work Environ Health. 1986 Feb;12(1):27-31. doi: 10.5271/sjweh.2177.
From 1975 to 1984, the incidence of cancer was determined among workers employed in a French man-made mineral fiber (MMMF) production plant. The cohort, including 1 374 fully active or retired men, represented 12 793 person-years. Forty-one patients had cancer, 19 of which were in the upper respiratory and alimentary tract and five of which were lung cancers. The number of lung cancers observed did not significantly differ from that expected [standardized incidence ration (SIR) 0.7]. However the incidence of upper respiratory and alimentary tract cancers was significantly higher (SIR 2.2), especially for those in the larynx (SIR = 2.3), pharynx (SIR 1.4), and buccal cavity (SIR 3.0). The relative risk of cancers in the upper respiratory and alimentary tracts seemed to increase with the length of exposure to glass fibers and exceeded the value of 3.0 for more than 10 years of exposure. This result does not seem to be attributable to an excess of tobacco and/or alcohol consumption. No previous survey of the MMMF industry has shown such a risk, except in Italy. Thus this finding has to be confirmed.
1975年至1984年期间，对一家法国人造矿物纤维（MMMF）生产厂的在职员工的癌症发病率进行了测定。该队列包括1374名在职或退休男性，总计12793人年。41名患者患有癌症，其中19例在上呼吸道和消化道，5例为肺癌。观察到的肺癌病例数与预期值无显著差异[标准化发病比（SIR）为0.7]。然而，上呼吸道和消化道癌症的发病率显著更高（SIR为2.2），尤其是喉癌（SIR = 2.3）、咽癌（SIR 1.4）和口腔癌（SIR 3.0）。上呼吸道和消化道癌症的相对风险似乎随着接触玻璃纤维的时长增加，且在接触超过10年时超过3.0。这一结果似乎并非归因于过量吸烟和/或饮酒。除意大利外，此前没有对MMMF行业的调查显示出此类风险。因此，这一发现有待证实。
