Elwood J M, Pearson J C, Skippen D H, Jackson S M
Int J Cancer. 1984 Nov 15;34(5):603-12. doi: 10.1002/ijc.2910340504.
A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and, less strongly, with smoking, which for all sites could be adequately fitted by either a multiplicative or an additive model. However, the site-specific relationships were different, alcohol consumption being significantly associated only with oral cavity, pharyngeal and extrinsic laryngeal tumours, and smoking only with intrinsic laryngeal tumours. Increased risks were associated with low socio-economic status, the unmarried state, and poor dental care. No significant associations were seen with specific occupational exposures.
本文报道了一项病例对照研究，研究对象为374例口腔、口咽和下咽以及喉原发性上皮癌患者，对照组为患有其他特定癌症的患者，按年龄和性别进行匹配。在所有符合条件的患者中，93%接受了访谈。饮酒会增加患癌风险，吸烟的影响相对较弱，对于所有部位，风险增加情况都可以用乘法模型或加法模型充分拟合。然而，特定部位的关系有所不同，饮酒仅与口腔、咽和喉外肿瘤显著相关，吸烟仅与喉内肿瘤相关。社会经济地位低、未婚状态和口腔护理差也会增加患癌风险。未发现与特定职业暴露有显著关联。
