Ihnat Jacqueline M H, De Baun Heloise, Carrillo Gabriel, Dony Alna, Mukherjee Thayer J, Ayyala Haripriya S
Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Am J Surg. 2025 Feb;240:116119. doi: 10.1016/j.amjsurg.2024.116119. Epub 2024 Nov 26.
Surgeons are likely to encounter patients on GLP-1 receptor agonists (GLP-1RAs) and should be aware of any associated risks or complications. Here we review the existing literature on GLP-1RA use as it pertains to non-bariatric surgeons.
A systematic review was conducted following PRISMA 2020 guidelines. Three databases were queried for articles discussing the use of GLP-1RAs in a surgical context. Articles went through two rounds of manual screening.
21 articles were included in analysis, which found that pre-operatively, GLP-1RAs can aid patients in meeting the BMI threshold for surgery. Peri-operatively, GLP-1RAs were associated with improved glycemic control and lower intraoperative insulin use. Complications such as delayed gastric emptying and increased rates of hypoglycemic events were reported.
Surgeons may leverage GLP-1RAs to help prepare patients for surgery and should understand potential surgical complications associated with the use of these medications and to screen preoperative patients appropriately.
外科医生可能会遇到正在使用胰高血糖素样肽-1受体激动剂（GLP-1RAs）的患者，应该了解任何相关风险或并发症。在此，我们回顾了现有关于GLP-1RAs使用的文献，这些文献与非减重外科医生相关。
按照PRISMA 2020指南进行系统综述。查询了三个数据库，以获取讨论在手术背景下使用GLP-1RAs的文章。文章经过两轮人工筛选。
21篇文章纳入分析，发现术前GLP-1RAs可帮助患者达到手术的体重指数阈值。围手术期，GLP-1RAs与改善血糖控制及减少术中胰岛素使用相关。报告了诸如胃排空延迟和低血糖事件发生率增加等并发症。
外科医生可利用GLP-1RAs帮助患者为手术做准备，并且应该了解与使用这些药物相关的潜在手术并发症，并对术前患者进行适当筛查。
