Wang Yuyan, Alptekin Ramazan, Goldring Roberta M, Oppenheimer Beno W, Shao Yongzhao, Reibman Joan, Liu Mengling
Department of Population Health, NYU Grossman School of Medicine, 180 Madison, New York, NY 10016, USA.
Department of Medicine, NYU Grossman School of Medicine, 550 1st Avenue, New York, NY 10016, USA.
Environ Pollut. 2025 Jan 15;365:125414. doi: 10.1016/j.envpol.2024.125414. Epub 2024 Nov 28.
Studies suggest that environmental disasters have a big impact on population health conditions including metabolic risk factors, such as obesity and hypertension. The World Trade Center (WTC) destruction from the 9/11 terrorist attack resulted in environmental exposures to community members (Survivors) with potential for metabolic effects. We now examine the impact of WTC exposure on Body Mass Index (BMI) using the data from 7136 adult participants enrolled in the WTC Environmental Health Center (EHC) from August 1, 2005, to December 31, 2022. We characterized WTC-related exposures by multiple approaches including acute dust-cloud exposure, occupational or residential exposures, and latent exposure patterns identified by synthesizing multiplex exposure questions using latent class analysis. Employing multivariable linear and quantile regressions for continuous BMI and ordered logistic regression for BMI categories, we found significant associations of BMI with WTC exposure categories or latent exposure patterns. For example, using exposure categories, compared to the group of local residents, local workers exhibited an average BMI increase of 1.71 kg/m with 95% confidence intervals (CI) of (1.33, 2.09), the rescue/recovery group had an increase of 3.13 kg/m (95% CI: 2.18, 4.08), the clean-up worker group had an increase of 0.75 kg/m (95% CI: 0.09, 1.40), and the other mixer group had an increase of 1.01 kg/m (95% CI: 0.43, 1.58). Furthermore, quantile regression analysis demonstrated that WTC exposures adversely affected the entire distribution of BMI in the WTC EHC Survivors, not merely the average. Our analysis also extended to blood pressure and hypertension, demonstrating statistically significant associations with WTC exposures. These outcomes highlight the intricate connection between WTC exposures and metabolic risk factors including BMI and blood pressure in the WTC Survivor population.
研究表明，环境灾难对包括肥胖和高血压等代谢风险因素在内的人群健康状况有重大影响。9·11恐怖袭击导致世界贸易中心（WTC）被毁，致使社区成员（幸存者）暴露于环境中，有可能产生代谢影响。我们现在利用2005年8月1日至2022年12月31日期间登记参加世界贸易中心环境卫生中心（EHC）的7136名成年参与者的数据，研究世贸中心暴露对体重指数（BMI）的影响。我们通过多种方法对与世贸中心相关的暴露进行了特征描述，包括急性尘云暴露、职业或居住暴露，以及通过使用潜在类别分析综合多重暴露问题确定的潜在暴露模式。对于连续的BMI，我们采用多变量线性回归和分位数回归，对于BMI类别采用有序逻辑回归，我们发现BMI与世贸中心暴露类别或潜在暴露模式之间存在显著关联。例如，使用暴露类别，与当地居民组相比，当地工人的BMI平均增加1.71kg/m²，95%置信区间（CI）为（1.33，2.09），救援/恢复组增加3.13kg/m²（95%CI：2.18，4.08），清理工人组增加0.75kg/m²（95%CI：0.09，1.40），其他混合组增加1.01kg/m²（95%CI：0.43，1.58）。此外，分位数回归分析表明，世贸中心暴露对世贸中心环境卫生中心幸存者的BMI整个分布产生了不利影响，而不仅仅是平均值。我们的分析还扩展到血压和高血压，表明与世贸中心暴露存在统计学上的显著关联。这些结果突出了世贸中心暴露与世贸中心幸存者群体中包括BMI和血压在内的代谢风险因素之间的复杂联系。
