Cordova-Gallardo Jacqueline, Vargas-Beltran Andres Manuel, Armendariz-Pineda Samantha Melanie, Ruiz-Manriquez Jesus, Ampuero Javier, Torre Aldo
Department of Gastroenterology, Service of Internal Medicine, General Hospital "Dr. Manuel Gea González", 14080 Mexico City, Mexico; Faculty of Medicine. National Autonomous University of Mexico, 04360 Mexico City, Mexico.
Department of Gastroenterology, Service of Internal Medicine, General Hospital "Dr. Manuel Gea González", 14080 Mexico City, Mexico; Faculty of Medicine, Meritorious Autonomous University of Puebla, 72420 Puebla, Mexico.
Ann Hepatol. 2025 Jan-Jun;30(1):101740. doi: 10.1016/j.aohep.2024.101740. Epub 2024 Nov 29.
Brain reserve is an important concept to understand the variability of damage associated with brain-related diseases and includes the adaptation of cognitive processes to preserve brain function. A good cognitive reserve might delay the onset of clinical manifestations of neurodegenerative diseases as well as hepatic encephalopathy, improving the quality of life in patients with chronic liver diseases. By stimulating activities and maintaining overall health, individuals may be able to enhance their brain's resilience to age-related changes and pathology. This review aims to collect all the data available on the role of brain reserve in hepatic encephalopathy development, and the potential effect of a good brain reserve in slowing down hepatic encephalopathy progression and frequency.
脑储备是理解与脑部相关疾病所导致损害变异性的一个重要概念，它包括认知过程的适应性以维持脑功能。良好的认知储备可能会延缓神经退行性疾病以及肝性脑病临床表现的出现，改善慢性肝病患者的生活质量。通过刺激活动和维持整体健康，个体或许能够增强其大脑对与年龄相关变化和病理状况的恢复能力。本综述旨在收集所有关于脑储备在肝性脑病发展中作用的现有数据，以及良好脑储备在减缓肝性脑病进展和发作频率方面的潜在影响。
