注意缺陷多动障碍功能性和结构性脑异常的多模态神经影像学荟萃分析。
A multimodal neuroimaging meta-analysis of functional and structural brain abnormalities in attention-deficit/hyperactivity disorder.
作者信息
Chen Chao, Sun Shilin, Chen Ruoyi, Guo Zixuan, Tang Xinyue, Chen Guanmao, Chen Pan, Tang Guixian, Huang Li, Wang Ying
机构信息
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China.
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Institute of Molecular and Functional Imaging, Jinan University, Guangzhou 510630, China.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111199. doi: 10.1016/j.pnpbp.2024.111199. Epub 2024 Nov 29.
BACKGROUND
Numerous neuroimaging studies utilizing resting-state functional imaging and voxel-based morphometry (VBM) have identified variations in distinct brain regions among individuals with attention-deficit/hyperactivity disorder (ADHD). However, the results have been inconsistent.
METHODS
A comprehensive voxel-wise meta-analysis was performed on studies employing resting-state functional imaging and gray matter volume (GMV), examining discrepancies between individuals with ADHD and neurotypical controls (NCs). The analysis utilized the Seed-based d Mapping software.
RESULTS
A systematic review of the literature identified 21 functional imaging studies (595 ADHD and 564 controls) and 50 GMV studies (1907 ADHD and 1611 controls). In general, individuals with ADHD exhibited increased resting-state functional activity in the right parahippocampal gyrus and bilateral orbitofrontal cortex (OFC), as well as decreased resting-state functional activity in the bilateral cingulate cortex (including the posterior cingulate cortex [PCC], median cingulate cortex [MCC], and anterior cingulate cortex [ACC]). The VBM meta-analysis revealed decreased GMV in the bilateral OFC, right putamen (extending to right superior temporal gyrus [STG]), left inferior frontal gyrus (IFG), right superior frontal gyrus (SFG), ACC, and precentral gyrus among individuals with ADHD.
CONCLUSIONS
The multimodal meta-analyses indicated that individuals with ADHD exhibit abnormalities in both function and structure in the bilateral OFC. In addition, a few regions exhibited only functional or only structural abnormalities in ADHD, such as in the limbic, prefrontal, primary sensorimotor regions.
背景
众多利用静息态功能成像和基于体素的形态测量学（VBM）的神经影像学研究已确定注意缺陷多动障碍（ADHD）患者不同脑区存在差异。然而，结果并不一致。
方法
对采用静息态功能成像和灰质体积（GMV）的研究进行全面的基于体素的荟萃分析，检查ADHD患者与神经典型对照（NCs）之间的差异。该分析使用基于种子的d映射软件。
结果
对文献的系统综述确定了21项功能成像研究（595名ADHD患者和564名对照）和50项GMV研究（1907名ADHD患者和1611名对照）。总体而言，ADHD患者在右侧海马旁回和双侧眶额皮质（OFC）的静息态功能活动增加，而在双侧扣带回皮质（包括后扣带回皮质[PCC]、中扣带回皮质[MCC]和前扣带回皮质[ACC]）的静息态功能活动减少。VBM荟萃分析显示，ADHD患者双侧OFC、右侧壳核（延伸至右侧颞上回[STG]）、左侧额下回（IFG）、右侧额上回（SFG）、ACC和中央前回的GMV减少。
结论
多模态荟萃分析表明，ADHD患者双侧OFC的功能和结构均存在异常。此外，ADHD患者的一些脑区仅表现出功能异常或仅表现出结构异常，如在边缘系统、前额叶、初级感觉运动区。
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