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社会人口因素和抑郁对精神分裂症药物依从性的影响：摩洛哥的横断面研究。

Impact of sociodemographic factors and depression on medication adherence in schizophrenia: Cross sectional study in Morocco.

机构信息

Clinical Neuroscience Laboratory (NICE), REGNE Research Laboratory, Faculty of Medicine and pharmacy, Ibn Zohr University, Agadir, Morocco.

Laboratory of Health Sciences, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco.

出版信息

Arch Psychiatr Nurs. 2024 Dec;53:62-70. doi: 10.1016/j.apnu.2024.09.008. Epub 2024 Oct 3.

DOI:10.1016/j.apnu.2024.09.008
PMID:39615946
Abstract

BACKGROUND

Medication non-adherence in schizophrenia is a major cause of relapse and hospitalization, presenting a significant challenge for clinicians. This study was conducted to estimate the prevalence of medication non-adherence and identify the impact of depression, as well as other factors, on medication adherence in individuals with schizophrenia.

METHODS

This was a cross-sectional study conducted among individuals with schizophrenia, both outpatients and inpatients. Data on sociodemographic, clinical, and therapeutic factors were collected using a dedicated questionnaire. Medication adherence and depression were assessed using two validated scales, the Medication Adherence Rating Scale (MARS) and the Calgary Depression Scale for Schizophrenia (CDSS), respectively.

RESULTS

Among the 305 participants included in this study, 21.3 % had poor medication adherence according to the MARS scores. The logistic regression model showed that only work and depression were significant predictors of poor medication adherence in individuals with schizophrenia.

CONCLUSION

The results of this study highlight a less explored factor that can influence medication adherence in individuals with schizophrenia, namely, depression. This underpins the importance of treating the non-psychotic dimensions of schizophrenia in the recovery process. However, further studies are needed to better characterize the pathways of medication adherence in schizophrenia.

摘要

背景

精神分裂症患者药物依从性差是导致复发和住院的主要原因，这给临床医生带来了巨大挑战。本研究旨在评估精神分裂症患者药物依从性的流行率，并确定抑郁等因素对药物依从性的影响。

方法

这是一项横断面研究，纳入了门诊和住院的精神分裂症患者。使用专门的问卷收集了社会人口学、临床和治疗因素的数据。使用两个经过验证的量表，即药物依从性评定量表（MARS）和 Calgary 精神分裂症抑郁量表（CDSS），分别评估了药物依从性和抑郁情况。

结果

在纳入的 305 名参与者中，根据 MARS 评分，21.3%的患者药物依从性差。逻辑回归模型显示，只有工作和抑郁是精神分裂症患者药物依从性差的显著预测因素。

结论

本研究结果突出了一个较不为人知的因素，即抑郁，它可以影响精神分裂症患者的药物依从性。这强调了在康复过程中治疗精神分裂症非精神病性维度的重要性。然而，需要进一步的研究来更好地描述精神分裂症药物依从性的途径。

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Impact of sociodemographic factors and depression on medication adherence in schizophrenia: Cross sectional study in Morocco.社会人口因素和抑郁对精神分裂症药物依从性的影响：摩洛哥的横断面研究。
Arch Psychiatr Nurs. 2024 Dec;53:62-70. doi: 10.1016/j.apnu.2024.09.008. Epub 2024 Oct 3.
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