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评估奥地利和德国器官移植的先进空中机动潜力。

Evaluation of the advanced air mobility potential for organ transplantation in Austria and Germany.

机构信息

Technical University Munich, Institute of Flight System Dynamics, Garching, 85748, Germany.

Clinical Department of General, Visceral, and Transplant Surgery, Medical University Graz, Graz, 8036, Austria.

出版信息

Sci Rep. 2024 Nov 30;14(1):29782. doi: 10.1038/s41598-024-81045-2.

Abstract

Solid organ transplantation continues to be the only or most efficient therapeutic solution for several end-stage diseases. The success of such transplantation is largely dependent on the swift transportation of organs from donors to recipients, as Cold Ischemia Time (CIT) plays a critical role in determining the recipient's medical outcome. This study explores the potential of Advanced Air Mobility (AAM) in the context of organ transplantation in Austria and Germany. AAM, in the healthcare sector, is associated with potential overall process time savings via air transportation, thereby reducing CIT. However, the application of AAM for organ transplantation has not yet been implemented in Europe. This study employs a Monte Carlo simulation to derive the trip length distributions for organ transplantation in Austria and Germany. By utilizing data from Eurotransplant (2018-2021) and ÖBIG (2017-2021), it was found that 48% of organ transports within Germany, and 80% of organ transports within Austria, fall within a trip length of less than 150 km. This distance is within the capabilities of today's AAM technology. Anticipated time benefits of up to 30 min compared to ground-based transport can be expected. Furthermore, the optimization of the organ transport process, facilitated by AAM, promises greater potential for CIT reduction.

摘要

实体器官移植仍然是治疗几种终末期疾病的唯一或最有效的治疗方法。这种移植的成功在很大程度上取决于器官从供体迅速运输到受者,因为冷缺血时间(CIT)在确定受者的医疗结果方面起着关键作用。本研究探讨了先进空中机动(AAM)在奥地利和德国器官移植背景下的潜力。在医疗保健领域,AAM 通过空运带来了潜在的整体过程时间节省,从而减少了 CIT。然而,AAM 在器官移植中的应用尚未在欧洲实施。本研究采用蒙特卡罗模拟方法得出了奥地利和德国器官移植的行程长度分布。利用 Eurotransplant(2018-2021 年)和ÖBIG(2017-2021 年)的数据,发现德国 48%的器官运输和奥地利 80%的器官运输的行程长度小于 150 公里。这一距离在当今 AAM 技术的能力范围内。与地面运输相比,预计可节省多达 30 分钟的预期时间。此外,AAM 促进的器官运输过程的优化有望带来更大的 CIT 减少潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c614/11608323/f71474ee2d6c/41598_2024_81045_Fig1_HTML.jpg

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