Zhang Wenjie, Shao Qing, Zhong Hua, Yang Yingying, Li Ruixue, Liu Yaxian, Hu Yi, Wang Penghui, Chi Bo
State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, PR China.
Kuitun Hospital of Ili prefecture, Kuitun, Xinjiang, Uyger Autonomous Region 833200, PR China.
Biomater Adv. 2025 Mar;168:214124. doi: 10.1016/j.bioadv.2024.214124. Epub 2024 Nov 26.
Skin anti-aging remains challenging due to the cumulative detrimental effects within the intricate microenvironment. Here, we present glycopeptide hydrogel (γ-PGA/HA) microneedle patches composed of poly (γ-glutamic acid) and hyaluronic acid as a potential solution. These microneedles aim to effectively penetrate the skin barrier while remodeling extracellular matrix to regulate the skin microenvironment. To align with clinical requirements, the functional properties of microenvironment regulation materials are characterized by testing the water absorption and retention, redox balance, and inflammatory microenvironment regulation ability. The γ-PGA/HA exhibited remarkable moisturizing, biocompatibility, fibroblast viability promotion, ROS consumption, and TNF-α inhibiting effects. Histological analysis provides empirical evidence supporting the functional efficacy of the microneedle, thus validating the anti-skin-aging potential of a model that mimics natural aging processes. Therefore, γ-PGA/HA holds promise for regulating the skin microenvironment, offering potential applications in skin aging treatments.
由于复杂微环境中累积的有害影响，皮肤抗老化仍然具有挑战性。在此，我们提出了一种由聚（γ-谷氨酸）和透明质酸组成的糖肽水凝胶（γ-PGA/HA）微针贴片作为一种潜在的解决方案。这些微针旨在有效穿透皮肤屏障，同时重塑细胞外基质以调节皮肤微环境。为了符合临床要求，通过测试吸水性和保水性、氧化还原平衡以及炎症微环境调节能力来表征微环境调节材料的功能特性。γ-PGA/HA表现出显著的保湿、生物相容性、促进成纤维细胞活力、消耗活性氧以及抑制肿瘤坏死因子-α的作用。组织学分析提供了支持微针功能功效的经验证据，从而验证了模拟自然衰老过程模型的抗皮肤老化潜力。因此，γ-PGA/HA在调节皮肤微环境方面具有前景，在皮肤老化治疗中具有潜在应用价值。
