Chen Kequan, Sun Xinyu, Liu Yangkaiyuan, Li Shiyu, Meng Dianhuai
The Second Clinical Medical School of Nanjing Medical University, Nanjing, China.
School of Biological Science & Medical Engineering, Southeast University, Nanjing, China.
Front Pharmacol. 2025 Jun 26;16:1607210. doi: 10.3389/fphar.2025.1607210. eCollection 2025.
Microneedle (MN) technology, characterized by its micron-scale structure, can effectively break through the skin barrier, enhance the efficiency of transdermal drug delivery and achieve precise biosignal detection. Research indicates that MNs demonstrate superior safety and efficacy in clinical applications, significantly improving drug delivery efficiency, enhancing patient compliance and reducing side effects. In the field of biosensing, the combination of MN arrays and biosensors enables highly sensitive real-time monitoring of biomarkers. In cancer treatment, MNs exhibit potential for targeted drug delivery, gene therapy, and immunostimulation. Moreover, MNs present broad prospects in wound healing, scar repair, anti-aging and skin disease treatment. This review aims to systematically summarize recent advances in MNs applications across transdermal drug delivery, biosensing, cancer therapy, and skin disease repair through recent high-quality studies, and to explore future development prospects.
微针（MN）技术以其微米级结构为特征，能够有效突破皮肤屏障，提高透皮给药效率，并实现精确的生物信号检测。研究表明，微针在临床应用中显示出卓越的安全性和有效性，显著提高了药物递送效率，增强了患者的依从性并减少了副作用。在生物传感领域，微针阵列与生物传感器的结合能够对生物标志物进行高灵敏度的实时监测。在癌症治疗中，微针在靶向给药、基因治疗和免疫刺激方面展现出潜力。此外，微针在伤口愈合、瘢痕修复、抗衰老和皮肤病治疗方面具有广阔前景。本综述旨在通过近期的高质量研究，系统总结微针在透皮给药、生物传感、癌症治疗和皮肤病修复等应用方面的最新进展，并探索未来的发展前景。
