Ghozal Manel, Delvert Rosalie, Adel-Patient Karine, Tafflet Muriel, Annesi-Maesano Isabella, Crépet Amélie, Sirot Véronique, Charles Marie Aline, Heude Barbara, Kadawathagedara Manik, de Lauzon-Guillain Blandine
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Université Paris-Saclay, UVSQ, Université Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, 94805, Villejuif, France.
Food Chem Toxicol. 2025 Feb;196:115167. doi: 10.1016/j.fct.2024.115167. Epub 2024 Nov 29.
Exposure to environmental chemicals has been associated with higher risk of childhood allergies. This study aimed to examine the association between infant's dietary exposure to mixtures of chemicals and allergic and respiratory multimorbidity in childhood. Dietary exposures were assessed at 8 and 12 months in 724 and 745 children of the EDEN cohort. Allergic and respiratory multimorbidity clusters were identified using latent class analyses. Associations between dietary exposure to mixtures of chemicals and allergic clusters were assessed by adjusted multinomial logistic regressions. At 8 months, higher exposure to a mixture of furans, trace elements, dioxins and PAHs was positively associated with the "asthma only" cluster, while moderate exposure to a mixture of PAHs, pesticides, PCBs and acrylamide was negatively associated with this cluster. A mixture of PCBs and BFRs was positively associated with the "multi-morbidity" cluster. Exposure to a mixture of pesticides and trace elements was positively associated with the "allergy without asthma" cluster. At 12-months, higher exposure to a mixture of trace elements and pesticides was positively associated with "multi-morbidity" cluster. The differences in findings between the two ages suggest the need for further studies to explore this critical window of chemical exposure and its impact on children's health.
接触环境化学物质与儿童过敏风险较高有关。本研究旨在探讨婴儿饮食中化学物质混合物暴露与儿童期过敏和呼吸道多种疾病之间的关联。对EDEN队列中724名和745名儿童在8个月和12个月时的饮食暴露情况进行了评估。使用潜在类别分析确定了过敏和呼吸道多种疾病集群。通过调整后的多项逻辑回归评估饮食中化学物质混合物暴露与过敏集群之间的关联。在8个月时，较高暴露于呋喃、微量元素、二恶英和多环芳烃的混合物与“仅哮喘”集群呈正相关，而适度暴露于多环芳烃、农药、多氯联苯和丙烯酰胺的混合物与该集群呈负相关。多氯联苯和溴化阻燃剂的混合物与“多种疾病”集群呈正相关。暴露于农药和微量元素的混合物与“无哮喘过敏”集群呈正相关。在12个月时，较高暴露于微量元素和农药的混合物与“多种疾病”集群呈正相关。两个年龄组研究结果的差异表明需要进一步研究来探索这个化学物质暴露的关键窗口期及其对儿童健康的影响。
