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肝小静脉闭塞病合并硬皮病并迅速进展至肝衰竭

Peliosis Hepatis Complicated by Scleroderma and Rapidly Progressing to Liver Failure.

机构信息

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Department of Pathology, Kindai University Faculty of Medicine, Japan.

出版信息

Intern Med. 2024;63(23):3171-3178. doi: 10.2169/internalmedicine.3508-24. Epub 2024 Dec 1.

DOI:10.2169/internalmedicine.3508-24
PMID:39617425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11671192/
Abstract

In November 2019, a 76-year-old woman was diagnosed with limited cutaneous scleroderma caused by Raynaud's phenomenon and skin hardening on the periphery of the extremities. In October 2022, blood tests and abdominal ultrasonography revealed liver dysfunction and multiple liver masses, respectively. In November 2022, a percutaneous liver mass biopsy revealed peliosis hepatitis, so the patient was referred to Kindai University Hospital, and signs of liver failure were observed. Considering her age, the patient was ineligible for liver transplantation, and she died in September 2023. Peliosis hepatis complicated by scleroderma has not been previously reported, so we report this as a valuable case.

摘要

2019 年 11 月，一位 76 岁女性被诊断为由雷诺现象引起的局限性硬皮病，四肢周围出现皮肤硬化。2022 年 10 月，血液检查和腹部超声检查分别显示肝功能异常和多个肝占位。2022 年 11 月，经皮肝肿块活检显示肝血窦扩张，因此患者被转介至近畿大学医院，观察到肝功能衰竭的迹象。考虑到她的年龄，患者不符合肝移植条件，于 2023 年 9 月死亡。硬皮病并发肝血窦扩张此前未有报道，因此我们将其作为一个有价值的病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/1333d7573c67/1349-7235-63-3171-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/1333d7573c67/1349-7235-63-3171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/473f15652d9a/1349-7235-63-3171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/133471af8706/1349-7235-63-3171-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/ae2472cf02e1/1349-7235-63-3171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/c0db4f72c166/1349-7235-63-3171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/9830d8ab1ae4/1349-7235-63-3171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6674/11671192/1333d7573c67/1349-7235-63-3171-g007.jpg

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Surg Case Rep. 2023 Nov 15;9(1):198. doi: 10.1186/s40792-023-01774-w.
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Systemic sclerosis interstitial lung disease: unmet needs and potential solutions.系统性硬皮病相关性间质性肺疾病：未满足的需求与潜在解决方案。
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Renal involvement in systemic sclerosis.
系统性硬化症的肾脏累及。
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Anabolic androgenic steroid-induced liver injury: An update.合成代谢雄激素类固醇诱导的肝损伤：最新进展。
World J Gastroenterol. 2022 Jul 14;28(26):3071-3080. doi: 10.3748/wjg.v28.i26.3071.
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Peliosis Hepatis due to Corticosteroid in Systemic Lupus Erythematosus.系统性红斑狼疮中因皮质类固醇导致的肝紫癜
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A Fatal Case of Intra-Abdominal Hemorrhage Following Diagnostic Blind Percutaneous Liver Biopsy in a Patient With Peliosis Hepatis.肝紫癜病患者经皮盲目肝穿刺活检后发生腹腔内出血致死1例
Gastroenterology Res. 2017 Oct;10(5):318-321. doi: 10.14740/gr873e. Epub 2017 Oct 26.
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