Department of Pharmacy, Konan Kosei Hospital.
Department of Infectious Diseases, Konan Kosei Hospital.
Med Mycol J. 2024;65(4):111-115. doi: 10.3314/mmj.24-00015.
Penicillium brasilianum is an environmental filamentous fungus with useful applications in biotechnology. However, human infections caused by P. brasilianum are rare and not well understood. We present the case of a woman in her sixties with poorly controlled diabetes mellitus who was diagnosed with invasive fungal rhinosinusitis (IFRS) and orbital apex syndrome. She underwent endoscopic sinus surgery and received treatment with liposomal amphotericin B. Notably, β-tubulin gene sequencing identified the filamentous fungus as P. brasilianum, and long-term itraconazole administration suppressed IFRS flares. Our findings underscore the need for increased awareness and understanding of rare fungal pathogens in clinical practice.
巴西青霉是一种环境丝状真菌，在生物技术中有广泛的应用。然而，由巴西青霉引起的人类感染较为罕见，目前人们对其了解还不够深入。我们报告了一例 60 多岁的女性糖尿病患者，其患有侵袭性真菌性鼻-鼻窦炎（IFRS）和眶尖综合征。患者接受了鼻内镜鼻窦手术，并接受了脂质体两性霉素 B 治疗。值得注意的是，β-微管蛋白基因测序鉴定出丝状真菌为巴西青霉，长期使用伊曲康唑可抑制 IFRS 发作。我们的研究结果强调了在临床实践中提高对罕见真菌病原体的认识和理解的必要性。
