Cochetti Giovanni, Del Zingaro Michele, Maiolino Giuseppe, Paladini Alessio, Mearini Matteo, Schiavina Riccardo, Bianchi Lorenzo, De Angelis Lorenzo, Panciarola Mattia, Camilloni Barbara, Brunocilla Eugenio, Mearini Ettore
Department of Medicine and Surgery, Urology Clinic, University of Perugia, Perugia, Italy.
Department of Urology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
Basic Clin Androl. 2024 Dec 2;34(1):24. doi: 10.1186/s12610-024-00236-z.
Despite numerous efforts to demonstrate the presence of the SARS-CoV-2 in semen of affected males, no clear evidence exists. We conducted a multicenter prospective study on adult patients with a confirmed diagnosis of SARS-CoV-2 including patients with active infection (Active Group) and with a history of COVID-19 disease at least of 6 months (Recovered Group). An RT-PCR test for SARS-CoV-2 and a semen analysis were performed on the semen of the enrolled patients. Genital/sexual symptoms were investigated in both groups. In the active infection group, urinary and sexual functions were assessed in the active phase and after 6 months. Finally, the literature on the detection of SARS-CoV-2 in semen was reviewed non-systematically.
Sixty-five patients were enrolled (Active Group = 15, Recovered Group = 50). RT-PCR testing for SARS-CoV-2 found no trace of the virus in any of the semen samples. Genital/sexual symptoms during the active phase were reported in 8 (12.2%) patients. No statistically significant differences in semen quality were found between the two groups. IPSS and IIEF-5 scores did not change significantly during the different phases of infection about (p > 0.05).
SARS-CoV-2 was not detected in semen of acute or recovered cases. Sperm parameters were not significantly different in the two groups. Urinary and erectile functions appeared stable across the phases of infection.
尽管人们为证明严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在受感染男性精液中的存在付出了诸多努力，但仍缺乏明确证据。我们对确诊为SARS-CoV-2的成年患者进行了一项多中心前瞻性研究，其中包括处于活跃感染期的患者（活跃组）和有至少6个月新冠病毒病病史的患者（康复组）。对入组患者的精液进行了SARS-CoV-2的逆转录聚合酶链反应（RT-PCR）检测和精液分析。对两组患者的生殖/性症状进行了调查。在活跃感染组中，在活跃期和6个月后对泌尿和性功能进行了评估。最后，对有关精液中SARS-CoV-2检测的文献进行了非系统性综述。
共入组65例患者（活跃组=15例，康复组=50例）。SARS-CoV-2的RT-PCR检测在任何精液样本中均未发现病毒踪迹。8例（12.2%）患者报告了活跃期的生殖/性症状。两组之间精液质量无统计学显著差异。在感染的不同阶段，国际前列腺症状评分（IPSS）和国际勃起功能指数-5（IIEF-5）评分无显著变化（p>0.05）。
在急性期或康复期病例的精液中未检测到SARS-CoV-2。两组的精子参数无显著差异。在感染的各个阶段，泌尿和勃起功能似乎稳定。
