Gupta Aditya K, Wang Tong, Rapaport Jeffrey A, Talukder Mesbah
Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mediprobe Research Inc., London, Ontario, Canada.
J Cosmet Dermatol. 2025 Feb;24(2):e16709. doi: 10.1111/jocd.16709. Epub 2024 Dec 1.
There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet-rich plasma represents an abundant source of exosomes.
To present evidence on the use of platelet-rich plasma-derived exosomes in dermatology and discuss current technical limitations.
A literature search was conducted using Embase (Ovid), Web of Science, and ClinicalTrials.gov in June 2024.
Platelet-rich plasma-derived exosomes contain a myriad of growth factors, genetic materials, and lipids that mediate paracrine signaling. Several preclinical studies have demonstrated their potential in wound healing. This includes faster wound contraction in diabetic animal models, as well as enhanced angiogenesis, increased cell proliferation and migration, and protection against hyperglycemic conditions in vitro. A case study reported a topical platelet-derived exosome product tried successfully in a patient with persistent scalp wounds. In contrast, there is scarce information on the use of platelet-rich plasma-derived exosomes in hair growth and skin rejuvenation. Isolation techniques, activation methods, and methods of delivery have not been optimized, which warrants further research. Novel delivery methods, such as hydrogel-based preparations, may enable the topical application of exosomes.
Exosomes derived from platelet-rich plasma have demonstrated therapeutic potential. More research is needed to standardize its use.
作为一种潜在的再生疗法，外泌体研究领域取得了令人兴奋的进展。富血小板血浆是外泌体的丰富来源。
提供关于富血小板血浆来源的外泌体在皮肤科应用的证据，并讨论当前的技术局限性。
2024年6月使用Embase（Ovid）、科学网和临床试验.gov进行文献检索。
富血小板血浆来源的外泌体含有多种生长因子、遗传物质和脂质，可介导旁分泌信号传导。多项临床前研究已证明其在伤口愈合方面的潜力。这包括在糖尿病动物模型中伤口收缩更快，以及在体外增强血管生成、增加细胞增殖和迁移，并预防高血糖状况。一项病例研究报告了一种局部应用的血小板衍生外泌体产品在一名患有持续性头皮伤口的患者中试用成功。相比之下，关于富血小板血浆来源的外泌体在毛发生长和皮肤年轻化方面的应用信息很少。分离技术、激活方法和递送方法尚未优化，这值得进一步研究。新型递送方法，如水凝胶制剂，可能使外泌体能够局部应用。
富血小板血浆来源的外泌体已显示出治疗潜力。需要更多研究来规范其使用。
