Burke A M, Younkin D, Gordon J, Goldberg H, Graham T, Kushner M, Obrist W, Jaggi J, Rosen M, Reivich M
Stroke. 1986 Mar-Apr;17(2):173-8. doi: 10.1161/01.str.17.2.173.
We prospectively studied 14 patients with acute cerebral infarctions using serial 133Xenon inhalation cerebral determination (133Xe-rCBF), scored neurological examinations, and neuropsychological testing. All patients underwent the same battery of tests at 3 days, 1 week, 2 weeks, and 4 weeks after cerebral infarction to determine the prognostic value of early rCBF studies and the chronological relationship of changes in rCBF to clinical status. Baseline rCBF within 3 days of symptoms of acute stroke did not correlate with clinical neurological outcome (r = -0.17, p less than 0.30; r = -0.18, p less than 0.28, for the two indices of rCBF used). Among the 11 patients demonstrating neurological recovery, 7 improved at 1 week, significantly before increases in rCBF (p less than 0.05). We conclude that early baseline rCBF does not predict clinical outcome in patients with acute cerebral infarctions and that return of neurological function precedes rather than follows increases in rCBF.
我们前瞻性地研究了14例急性脑梗死患者，采用连续吸入133氙进行脑血流量测定（133Xe-rCBF）、神经学检查评分及神经心理学测试。所有患者在脑梗死发生后的3天、1周、2周和4周接受相同的一系列检查，以确定早期rCBF研究的预后价值以及rCBF变化与临床状态的时间关系。急性卒中症状出现3天内的基线rCBF与临床神经学转归无相关性（对于所使用的两个rCBF指标，r分别为-0.17，p<0.30；r为-0.18，p<0.28）。在11例显示神经功能恢复的患者中，7例在1周时有所改善，明显早于rCBF升高（p<0.05）。我们得出结论，急性脑梗死患者的早期基线rCBF不能预测临床转归，神经功能恢复先于rCBF升高而非在其之后。
