MacInnes W D, Golden C J, Gillen R W, Sawicki R F, Quaife M, Uhl H S, Greenhouse A J
J Am Geriatr Soc. 1984 Oct;32(10):712-8. doi: 10.1111/j.1532-5415.1984.tb04169.x.
Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria-Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy-nine elderly volunteers (56-88 years old), both healthy and demented, underwent the 133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray-matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray-matter blood flow and the LNNB scales. However, there was much less of a relationship between white-matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning.
以往的研究发现，局部脑血流量（rCBF）模式的变化与年龄及各种认知任务均有关联。然而，尚无研究证实老年人群体中rCBF与鲁利亚-内布拉斯加神经心理成套测验（LNNB）成绩之间存在关联。79名年龄在56至88岁之间的老年志愿者，包括健康者和痴呆患者，接受了吸入133氙的rCBF检测，并进行了LNNB测试。灰质血流量的减少与LNNB成绩的下降平行。通过偏相关分析发现，灰质血流量与LNNB各量表之间存在显著比例的共同方差。然而，白质血流量与LNNB成绩之间的关系则弱得多。这项研究表明，即使在年龄范围有限的样本中，rCBF与神经心理功能也存在整体关联。
