Bojsen-Møller Emil, Bolam Kate A, Väisänen Daniel, Paulsson Sofia, Lindwall Magnus, Rundqvist Helene, Nyberg Jenny, Åberg Maria, Ekblom-Bak Elin
Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Cardiometabolic Health and Exercise Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
Cancer Med. 2024 Dec;13(23):e70430. doi: 10.1002/cam4.70430.
The aim of this prospective cohort study was to investigate the associations between changes in cardiorespiratory fitness (CRF) and the risk of colorectal and prostate cancer in men.
Data from men who completed a health assessment both in military conscription in youth and an occupational health profile assessment (HPA) later in life were used. CRF was assessed as estimated V̇O, using a cycle ergometer fitness test at both time points. We linked the assessment data to national register data on colorectal and prostate cancer incidence, and hazard ratios and confidence intervals were estimated using Cox proportional hazard regression.
139,764 men with a mean age of 18 (SD 0.6) at conscription and 43 (SD 8.9) at HPA were included. The average time between the two assessments was 25.9 (SD 9.0) years and mean follow-up time following HPA test was 10.0 (SD 5.6) years for prostate and colorectal cancer. Annual percentage change in relative and absolute V̇O from conscription to HPA was inversely associated with the risk of colorectal cancer incidence, hazard ratio of 0.83 (95% CI [0.72-0.94]) and 0.88 (95% CI [0.79-0.99]), respectively. These associations were driven by data from individuals in the lowest and moderate level fitness tertials at conscription. Change in CRF was not associated with prostate cancer incidence risk.
Changes in, not only level of, CRF from youth to adulthood are related to colorectal cancer incidence risk and therefore, improving CRF should be considered as an important colorectal cancer risk reduction strategy.
这项前瞻性队列研究的目的是调查男性心肺适能（CRF）变化与结直肠癌和前列腺癌风险之间的关联。
使用了男性的数据，这些男性在年轻时进行征兵健康评估，后来又进行了职业健康状况评估（HPA）。在两个时间点均使用自行车测力计健身测试将CRF评估为估计的摄氧量（V̇O）。我们将评估数据与结直肠癌和前列腺癌发病率的国家登记数据相链接，并使用Cox比例风险回归估计风险比和置信区间。
纳入了139,764名男性，征兵时平均年龄为18岁（标准差0.6），HPA时平均年龄为43岁（标准差8.9）。两次评估之间的平均时间为25.9年（标准差9.0），HPA测试后前列腺癌和结直肠癌的平均随访时间为10.0年（标准差5.6）。从征兵到HPA，相对和绝对V̇O的年百分比变化与结直肠癌发病风险呈负相关，风险比分别为0.83（95%置信区间[0.72 - 0.94]）和0.88（95%置信区间[0.79 - 0.99]）。这些关联是由征兵时处于最低和中等适能三分位数的个体数据驱动的。CRF的变化与前列腺癌发病风险无关。
从青年到成年，不仅CRF水平的变化与结直肠癌发病风险有关联，因此，应将改善CRF视为降低结直肠癌风险的一项重要策略。
