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Heliyon. 2023 Jul 7;9(7):e17980. doi: 10.1016/j.heliyon.2023.e17980. eCollection 2023 Jul.
2
A global science mapping analysis on odontogenic infections.牙源性感染的全球科学图谱分析。
J Stomatol Oral Maxillofac Surg. 2024 Sep;125(4S):101513. doi: 10.1016/j.jormas.2023.101513. Epub 2023 May 18.
3
Evolution of the treatment of severe odontogenic infections over 50 years: A comprehensive review.50年来严重牙源性感染治疗方法的演变:一项全面综述。
J Taibah Univ Med Sci. 2022 Sep 15;18(2):225-233. doi: 10.1016/j.jtumed.2022.08.008. eCollection 2023 Apr.
4
Relationship between mysticism and severe odontogenic infections in Africa: what to do?神秘主义与非洲严重牙源性感染的关系:该如何应对?
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Sep;134(3):e51-e53. doi: 10.1016/j.oooo.2022.01.008. Epub 2022 Jan 16.
5
Biological factors predicting the length of hospital stay in odontogenic cellulitis.预测牙源性蜂窝织炎住院时间的生物学因素。
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6
Comparison of sensitivity of bacteria isolated in odontogenic infections to ceftriaxone and amoxicillin-clavulanate.牙源性感染中分离出的细菌对头孢曲松和阿莫西林-克拉维酸的敏感性比较。
Afr Health Sci. 2019 Sep;19(3):2414-2420. doi: 10.4314/ahs.v19i3.15.
7
Spread of odontogenic infections in Port Harcourt, Nigeria.尼日利亚哈科特港牙源性感染的传播
J Oral Maxillofac Surg. 2010 Oct;68(10):2472-7. doi: 10.1016/j.joms.2010.01.019. Epub 2010 Jul 15.
8
Necrotizing fasciitis caused by dental infection: a retrospective analysis of 9 cases and a review of the literature.牙源性感染所致坏死性筋膜炎:9例回顾性分析及文献复习
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Mar;95(3):283-90. doi: 10.1067/moe.2003.85.
9
Cervical necrotizing fasciitis of odontogenic origin: a report of 11 cases.牙源性颈深部坏死性筋膜炎:11例报告
J Oral Maxillofac Surg. 2000 Dec;58(12):1347-52; discussion 1353. doi: 10.1053/joms.2000.18259.

牙源性坏死性筋膜炎治疗方案的四年经验

Four-Year Experience with Treatment Protocol for Odontogenic Necrotizing Fasciitis.

作者信息

Lucamba Agnelo, Grillo Ricardo, Filipe Luzolo, Fernandes Maria Teresa

机构信息

Department of Oral and Maxillofacial Surgery, Hospital Josina Machel, Luanda, Angola.

Oral and Maxillofacial Surgery Training Program, Foundation of Dentistry - Fundecto, University of São Paulo, São Paulo, Brazil.

出版信息

J Maxillofac Oral Surg. 2024 Dec;23(6):1564-1568. doi: 10.1007/s12663-024-02302-5. Epub 2024 Aug 10.

DOI:10.1007/s12663-024-02302-5
PMID:39618434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11607231/
Abstract

Odontogenic infections, irrespective of regional economic conditions, are a global health concern. Some cases escalate to severe levels, complicating treatment, endangering lives, and reducing positive outcomes. Necrotizing fasciitis is particularly lethal, with purulent collections and infection-derived gases spreading to distant regions. Prompt surgical intervention is crucial, especially in patients with comorbidities like diabetes mellitus. This paper introduces a comprehensive treatment approach taken in Angola over the past 4 years. This protocol involves four key steps: combined antibiotic therapy (ceftriaxone, metronidazole, and aminoglycoside), prompt drainage with aggressive debridement, irrigation with sodium hypochlorite, and rapid removal of the infectious focus. This study reports its application in 13 patients over a 10-day period, demonstrating its efficacy in odontogenic necrotizing fasciitis. The protocol significantly reduced fatalities, and its success was acknowledged by the maxillofacial surgery department at Josina Machel Hospital. Challenges, such as a scarcity of maxillofacial surgeons, prompted innovative adaptations to treatment protocols. Although lacking statistical validation, the used protocol showcased effectiveness in treating odontogenic necrotizing fasciitis. Its emphasis on combined antibiotic therapy, aggressive surgical interventions, and specialized irrigation demonstrated notable success in reducing mortality rates.

摘要

无论地区经济状况如何,牙源性感染都是一个全球关注的健康问题。一些病例会升级到严重程度,使治疗复杂化,危及生命,并降低积极的治疗效果。坏死性筋膜炎尤其致命,脓性分泌物和感染产生的气体可扩散到远处。及时的手术干预至关重要,尤其是对于患有糖尿病等合并症的患者。本文介绍了安哥拉在过去4年中采取的综合治疗方法。该方案包括四个关键步骤:联合抗生素治疗(头孢曲松、甲硝唑和氨基糖苷类)、积极清创引流、用次氯酸钠冲洗以及迅速清除感染灶。本研究报告了该方案在10天内对13例患者的应用情况,证明了其在牙源性坏死性筋膜炎治疗中的有效性。该方案显著降低了死亡率,其成功得到了若西纳·马谢尔医院颌面外科的认可。诸如颌面外科医生短缺等挑战促使对治疗方案进行创新调整。尽管缺乏统计学验证,但所采用的方案在治疗牙源性坏死性筋膜炎方面显示出有效性。其对联合抗生素治疗、积极手术干预和专门冲洗的强调在降低死亡率方面取得了显著成功。