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根治性前列腺切除术后的生存状况:我们真正在问什么?

Radical Prostatectomy Survivorship: What Are We Really Asking?

作者信息

Merrett Christopher, Yim Arthur, Ong Xuan Rui Sean, Silagy Benjamin, Al-Khanaty Abdullah, Stokes Deborah, Slade Kate, Blecher Gideon

机构信息

Urology, Monash Health, Melbourne, AUS.

Urology, Alfred Health, Melbourne, AUS.

出版信息

Cureus. 2024 Oct 31;16(10):e72744. doi: 10.7759/cureus.72744. eCollection 2024 Oct.

DOI:10.7759/cureus.72744
PMID:39618609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11607558/
Abstract

Introduction Urinary incontinence, sexual dysfunction, and bowel dysfunction are well-recognized cancer survivorship outcomes affected by radical prostatectomy (RP) in the treatment of prostate cancer (PCa).The aim of this study was to audit the thoroughness of outpatient discussions and documentation of survivorship outcomes for patients who have undergone RP. Methods This was a retrospective audit of all 253 radical prostatectomies conducted at two tertiary-level Australian institutions (Monash Medical Centre and Alfred Hospital), over a five-year period between 2014 and 2018. Electronic medical records were reviewed across five time points: preoperative and then six weeks, three months, six months, and 12 months post-RP.The main outcomes measured were rates of documented discussions of urinary incontinence, sexual dysfunction, and bowel dysfunction. Results At the initial six-week postoperative review, there was an 86%, 47%, and 27% probability that urinary, sexual, and bowel functions were discussed and documented. When averaging across the four postoperative time points, from six weeks to 12 months, there was a 73%, 45%, and 14% respective rate of documented discussion for each survivorship outcome. Sexual and bowel function discussions were less frequently documented in men over 65 years of age compared with those under 65 years of age by 16% (p < 0.001) and 8% (p = 0.003), respectively. Conclusion Sexual and bowel dysfunction were less frequently discussed and documented in the follow-up of our cohort of RP patients compared with urinary continence outcomes.

摘要

引言

尿失禁、性功能障碍和肠道功能障碍是前列腺癌(PCa)根治性前列腺切除术(RP)治疗中公认的癌症幸存者结局。本研究的目的是审核对接受RP治疗患者的门诊讨论及幸存者结局记录的完整性。

方法

这是一项对澳大利亚两家三级医疗机构(莫纳什医疗中心和阿尔弗雷德医院)在2014年至2018年五年期间进行的所有253例根治性前列腺切除术的回顾性审核。在五个时间点审查电子病历:术前以及RP术后六周、三个月、六个月和12个月。主要测量的结局是记录尿失禁、性功能障碍和肠道功能障碍讨论的比例。

结果

在术后最初六周的复查中,讨论并记录排尿、性功能和肠道功能的概率分别为86%、47%和27%。在术后四个时间点(从六周至12个月)平均计算时,每个幸存者结局的记录讨论比例分别为73%、45%和14%。65岁以上男性与65岁以下男性相比,性功能和肠道功能讨论的记录频率分别低16%(p<0.001)和8%(p = 0.003)。

结论

与尿失禁结局相比,在我们的RP患者队列随访中,性功能和肠道功能障碍的讨论和记录频率较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e71/11607558/caf35dea0ce1/cureus-0016-00000072744-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e71/11607558/491417ede4c7/cureus-0016-00000072744-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e71/11607558/caf35dea0ce1/cureus-0016-00000072744-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e71/11607558/491417ede4c7/cureus-0016-00000072744-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e71/11607558/caf35dea0ce1/cureus-0016-00000072744-i02.jpg

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本文引用的文献

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Epidemiology, Staging and Management of Prostate Cancer.前列腺癌的流行病学、分期与管理
Med Sci (Basel). 2020 Jul 20;8(3):28. doi: 10.3390/medsci8030028.
2
Reconsideration of pelvic floor muscle training to prevent and treat incontinence after radical prostatectomy.重新考虑骨盆底肌肉训练以预防和治疗根治性前列腺切除术后的尿失禁。
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Erectile Function and Sexual Satisfaction: The Importance of Asking About Sexual Desire.勃起功能和性满意度:询问性欲的重要性。
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Management of erectile dysfunction post-radical prostatectomy.根治性前列腺切除术后勃起功能障碍的管理
Res Rep Urol. 2015 Feb 23;7:19-33. doi: 10.2147/RRU.S58974. eCollection 2015.
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Oncol Nurs Forum. 2013 Nov;40(6):575-80. doi: 10.1188/13.ONF.575-580.
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Eur Urol. 2012 Dec;62(6):976-83. doi: 10.1016/j.eururo.2012.05.072. Epub 2012 Jun 7.
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Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function.前列腺切除术后性功能障碍的预防和管理第 2 部分:勃起功能、性欲和性高潮功能的恢复和保护。
Eur Urol. 2012 Aug;62(2):273-86. doi: 10.1016/j.eururo.2012.04.047. Epub 2012 May 3.
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Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis.抑郁和性功能障碍之间的双向关联:系统评价和荟萃分析。
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