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新冠病毒感染后系统性血管炎:一例报告

Systemic Vasculitis Post-COVID-19: A Case Report.

作者信息

Nahar Shamsun, Husain Mohammad M, Maharaj Akshay, Lakkimsetti Mohit, Vemoori Yashwanth, Karim Mohammad Nazmul, Saaki Shaila S, Oeshe Farhana Binta Awal, Begum Rokeya

机构信息

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Internal Medicine, Kansas City University of Medicine and Biosciences, Fort Myers, USA.

出版信息

Cureus. 2024 Oct 30;16(10):e72724. doi: 10.7759/cureus.72724. eCollection 2024 Oct.

DOI:10.7759/cureus.72724
PMID:39618677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11606616/
Abstract

Vasculitis is one of the complications of COVID. Coronavirus may trigger or exacerbate autoimmune diseases, such as systemic vasculitis. We present the case of an elderly individual with a medical history that includes recurrent urinary tract infections, hyperlipidemia, essential hypertension, and peripheral vascular disease. Doctors suspected vasculitis due to declining renal function, clinical condition, and serological findings of the patient. His serum tested positive for antinuclear antibodies. A kidney biopsy was deemed necessary due to the unclear cause of his renal insufficiency. The biopsy revealed focal necrotizing and crescentic glomerulonephritis (GN), a pauci-immune type. It is essential to learn more about COVID-19 and its related complications. This case highlights the difficulties of COVID-19, leading to focal necrotizing and crescentic GN. Maintaining a broad differential is essential while treating a patient who has recovered from the initial infection. This research is important because it will help clinicians to identify this perspective while treating patients. We also review some related articles on the association of COVID-19 with vasculitis.

摘要

血管炎是新冠病毒感染的并发症之一。冠状病毒可能引发或加重自身免疫性疾病,如系统性血管炎。我们报告一例老年患者,其病史包括复发性尿路感染、高脂血症、原发性高血压和外周血管疾病。由于患者肾功能下降、临床状况及血清学检查结果,医生怀疑为血管炎。其血清抗核抗体检测呈阳性。由于肾功能不全病因不明,故认为有必要进行肾活检。活检显示为局灶性坏死性新月体性肾小球肾炎(GN),为寡免疫型。有必要进一步了解新冠病毒及其相关并发症。该病例突出了新冠病毒感染的难点,可导致局灶性坏死性新月体性肾小球肾炎。在治疗已从初始感染中康复的患者时,保持广泛的鉴别诊断至关重要。这项研究很重要,因为它将帮助临床医生在治疗患者时识别这一情况。我们还回顾了一些关于新冠病毒与血管炎关联的相关文章。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e989/11606616/fd9dfe293979/cureus-0016-00000072724-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e989/11606616/572608d728cf/cureus-0016-00000072724-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e989/11606616/fd9dfe293979/cureus-0016-00000072724-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e989/11606616/572608d728cf/cureus-0016-00000072724-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e989/11606616/fd9dfe293979/cureus-0016-00000072724-i02.jpg

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本文引用的文献

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COVID-19 associated vasculitis: A systematic review of case reports and case series.新型冠状病毒肺炎相关血管炎:病例报告和病例系列的系统评价
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Rheumatol Int. 2021 Aug;41(8):1523-1529. doi: 10.1007/s00296-021-04914-3. Epub 2021 Jun 7.
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Effects of the COVID-19 Pandemic on Patients Living With Vasculitis.新冠疫情对血管炎患者的影响。
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Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review.成人 COVID-19 相关的自身免疫和风湿表现:一项更新的系统评价。
Front Immunol. 2021 Mar 12;12:645013. doi: 10.3389/fimmu.2021.645013. eCollection 2021.
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Risk Factors for Severe Outcomes in Patients With Systemic Vasculitis and COVID-19: A Binational, Registry-Based Cohort Study.COVID-19 合并系统性血管炎患者发生重症结局的危险因素:一项基于注册的两国队列研究。
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