Mittal Saurabh, Mittal Prateek, Singh Ruhi, Gupta Simran, Singh Taniya, Khan Rahmuddin, Alzobaidi Nafaa, Alhalmi Abdulsalam
Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Center of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida 201303, Uttar Pradesh, India.
Scientifica (Cairo). 2024 Nov 22;2024:9978076. doi: 10.1155/2024/9978076. eCollection 2024.
The issue of drug resistance and tolerance presents a significant challenge as it diminishes the efficacy and potency of medications, posing a formidable obstacle for physicians striving to enhance pharmacological therapy worldwide. These resistance mechanisms can arise from genetic predispositions or as a consequence of medical interventions. Notably, acquired resistance or tolerance may extend to other drugs within the same or different classes, despite differing mechanisms of action. This phenomenon leads to the ineffectiveness of various pharmacological treatments over time, hindering the attainment of complete remission for numerous illnesses spanning metabolic disorders, autoimmune diseases, carcinomas, infectious diseases, cardiovascular diseases, and neurological disorders. Vitamin D, an essential lipid-soluble nutrient crucial for regulating calcium and phosphorus levels, is emerging as a potential solution to counteract treatment resistance and tolerance in various conditions such as cancer, tuberculosis, and depression. This review scrutinizes existing research and offers insights for future investigations aimed at fully elucidating the therapeutic potential of vitamin D in mitigating the challenges associated with prolonged medication regimens and drug treatment failures. ClinicalTrials.gov identifier: NCT01169259 and NCT04342598.
耐药性和耐受性问题构成了一项重大挑战，因为它会降低药物的疗效和效力，给全球致力于加强药物治疗的医生带来巨大障碍。这些耐药机制可能源于遗传倾向或医疗干预的结果。值得注意的是，获得性耐药或耐受性可能会扩展到同一类或不同类别的其他药物，尽管其作用机制不同。随着时间的推移，这种现象导致各种药物治疗失效，阻碍了许多疾病实现完全缓解，这些疾病包括代谢紊乱、自身免疫性疾病、癌症、传染病、心血管疾病和神经系统疾病。维生素D是一种对调节钙和磷水平至关重要的必需脂溶性营养素，正成为应对癌症、结核病和抑郁症等各种病症治疗耐药性和耐受性的潜在解决方案。本综述审视现有研究，并为未来调查提供见解，旨在充分阐明维生素D在减轻与长期药物治疗方案和药物治疗失败相关挑战方面的治疗潜力。ClinicalTrials.gov标识符：NCT01169259和NCT04342598。
