Chen Ying, Xu Qinglin, Lv Lu, Liu Yun, Zhang Zhidan, Yang Zhikuan
Department of Optometry and Pediatric Ophthalmology, Aier Eye Hospital, Jinan University, Guangzhou, Guangdong, China.
Department of Pediatric Ophthalmology, Aier Eye Hospital of Wuhan University (Wuhan Aier Eye Hospital), Wuhan, Hubei, China.
Front Pediatr. 2024 Nov 15;12:1503926. doi: 10.3389/fped.2024.1503926. eCollection 2024.
The study aimed to explore the relationship of anthocyanin and its subtypes with myopia in adolescents aged 12-17 years.
Adolescents data for this cross-sectional study were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007-2008. Anthocyanin and subtypes were obtained using the Nutrient Database for Dietary Studies codes. Myopia was defined as a spherical equivalent of -1.0 diopters or less. The relationships between anthocyanin and subtypes intake and myopia were determined utilizing weighted univariate and multivariate logistic regression models. The relationships were also explored in gender, leisure time, physical activity, sedentary activity, BMI, and serum cotinine subgroups.
A total of 839 adolescents were included for further analysis, among them 245 have myopia. Malvidin (34.98%) was the subtype with the largest anthocyanin intake, followed by cyanidin (22.94%). Compared to adolescents without anthocyanin intake, total anthocyanin intake was related to a lower incidence of myopia (OR = 0.69, 95%CI: 0.51-0.92). Higher intake of cyanidin (OR = 0.69, 95%CI: 0.52-0.92), petunidin (OR = 0.64, 95%CI: 0.42-0.97), and delphinidin (OR = 0.71, 95%CI: 0.51-0.99) were associated with lower odds of myopia in adolescents. Higher total anthocyanin intake was related to lower odds of myopia in those females, leisure time physical activity ≥60 min/day, sedentary time <8 h/day, overweight or obese, and serum cotinine ≥0.05 ng/ml.
Higher total anthocyanin intake, particularly cyanidin, petunidin, and delphinidin, was related to a lower incidence of myopia in adolescents. Increasing dietary anthocyanin intake may be an effective prevention strategy for ocular health.
本研究旨在探讨花青素及其亚型与12至17岁青少年近视的关系。
这项横断面研究的青少年数据取自2007 - 2008年国家健康与营养检查调查（NHANES）。花青素及其亚型通过膳食研究营养数据库编码获取。近视定义为等效球镜度数为-1.0屈光度或更低。利用加权单变量和多变量逻辑回归模型确定花青素及其亚型摄入量与近视之间的关系。还在性别、休闲时间、体育活动、久坐活动、体重指数和血清可替宁亚组中探讨了这些关系。
共有839名青少年纳入进一步分析，其中245人患有近视。矢车菊素（34.98%）是花青素摄入量最高的亚型，其次是花青素（22.94%）。与未摄入花青素的青少年相比，总花青素摄入量与较低的近视发病率相关（OR = 0.69，95%CI：0.51 - 0.92）。较高的花青素摄入量（OR = 0.69，95%CI：0.52 - 0.92）、矮牵牛素（OR = 0.64，95%CI：0.42 - 0.97）和飞燕草素（OR = 0.71，95%CI：0.51 - 0.99）与青少年较低的近视几率相关。较高的总花青素摄入量与女性、休闲时间体育活动≥60分钟/天、久坐时间<8小时/天、超重或肥胖以及血清可替宁≥0.05 ng/ml的青少年较低的近视几率相关。
较高的总花青素摄入量，尤其是花青素、矮牵牛素和飞燕草素，与青少年较低的近视发病率相关。增加膳食花青素摄入量可能是一种有效的眼部健康预防策略。
