评估与非酒精性脂肪性肝病相关的微小RNA在肝细胞癌肿瘤发生中的作用：一项系统综述和网络分析

Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis.

作者信息

Peng Qinghua, Zhu Xiaoning, Jiang Yuanyuan, Peng Mengyun, Zheng Ding, Wang Xiaodong, Cheah Yoke Kqueen, Wang Jing

机构信息

Hepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.

Sichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.

出版信息

Front Med (Lausanne). 2024 Nov 15;11:1462513. doi: 10.3389/fmed.2024.1462513. eCollection 2024.

DOI:10.3389/fmed.2024.1462513

PMID:39618816

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11604432/

Abstract

INTRODUCTION

Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC.

METHOD

Potential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis.

RESULT

MIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions.

CONCLUSION

MIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO, identifier: CRD 42024517940.

摘要

引言

非酒精性脂肪性肝病（NAFLD）已成为全球慢性肝病的主要病因。肝细胞癌（HCC）是全球第五大常见恶性肿瘤，发病率和死亡率都很高。NAFLD发病率的迅速上升正成为全球HCC的重要前驱因素。微小RNA（miRNA）参与了NAFLD和HCC的进展。

方法

通过系统综述确定了与HCC肿瘤发生中NAFLD相关的潜在miRNA，并通过数据挖掘分析评估了它们的作用。通过生物信息学分析评估了潜在miRNA及其靶基因在NAFLD和HCC中的生物学功能。

结果

MIR122被确定为与NAFLD和HCC相关的潜在miRNA。然后，MIR122在HCC患者中的表达显著降低了，而较高的MIR122水平与显著更好的总生存期相关。接下来，预测MIR122和靶基因的生物学功能参与炎症、纤维化、细胞增殖、侵袭、转移和凋亡。特别是，FOXO信号通路可能调节上述生物学功能。