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血浆去甲氯丙嗪浓度：年龄、种族和性别的影响。

Plasma nor1-chlorpromazine concentrations: effects of age, race, and sex.

作者信息

Young R C

出版信息

Ther Drug Monit. 1986;8(1):23-6. doi: 10.1097/00007691-198603000-00005.

DOI:10.1097/00007691-198603000-00005
PMID:3961892
Abstract

Plasma nor1-chlorpromazine (nor1-CPZ) and chlorpromazine concentrations were measured by gas chromatography--mass fragmentometry in 15 inpatients receiving stable doses of chlorpromazine. Nor1-CPZ concentrations averaged 20% of chlorpromazine concentrations and were highly correlated with them. Relative concentrations of nor1-CPZ increased with age. Nor1-CPZ concentrations per milligram dose were higher in black than in white patients.

摘要

采用气相色谱-质谱碎片分析法测定了15例接受稳定剂量氯丙嗪治疗的住院患者血浆中去甲-1-氯丙嗪（nor1-CPZ）和氯丙嗪的浓度。去甲-1-氯丙嗪浓度平均为氯丙嗪浓度的20%，且两者高度相关。去甲-1-氯丙嗪的相对浓度随年龄增长而升高。每毫克剂量的去甲-1-氯丙嗪浓度在黑人患者中高于白人患者。

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