Chetty M, Miller R, Moodley S V
Drug Studies Unit, University of Durban-Westville, South Africa.
Eur J Clin Pharmacol. 1994;46(6):523-6. doi: 10.1007/BF00196109.
The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients. A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.
利用31例慢性精神分裂症患者的189次血浆浓度测量值，评估了氯丙嗪（CPZ）在这些患者中的群体药代动力学参数。NONMEM分析表明，CPZ的清除率取决于患者的体重。吸烟和吸食大麻会增加CPZ的清除率。长期饮酒以及同时使用抗胆碱能药物似乎对CPZ的清除率没有显著影响。
