Das Avijit Kumar
Department of Chemistry, Christ University Hosur Road Bangalore Karnataka 560029 India
RSC Med Chem. 2024 Nov 13. doi: 10.1039/d4md00661e.
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive survey of the recent advancements in sensing technologies for NSAIDs, focusing on molecular receptors and nanostructured assemblies. Molecular receptors based on different fluorescent molecules such as anthracene, naphthalimide, squaraine, quinoline, BINOL, offer high selectivity and sensitivity for NSAID detection. In parallel, nanostructured assemblies including CdSe/ZnS, Cd/S quantum dots (QDs), carbon dot-containing imprinted polymers, Ag and Au nanoparticles (NPs), hydrogel-embedded chemosensors, were utilized for NSAID detection. This review highlights the different binding pathways with the change of various photophysical properties combining molecular recognition elements with nanomaterials to develop innovative sensors that achieve rapid, sensitive, and selective detection of NSAIDs. The review also discusses current challenges and future prospects in the field and based on reported designed receptors and nanostructured assemblies. To the best of our knowledge, no reviews have been reported on this topic so far. Thus, this review will fruitfully guide researchers to design various new molecular receptors and nanostructured materials to detect NSAIDs.
非甾体抗炎药（NSAIDs）的检测和定量分析至关重要，因为它们被广泛使用，并且对人类健康和环境具有潜在影响。本综述全面概述了NSAIDs传感技术的最新进展，重点关注分子受体和纳米结构组件。基于蒽、萘酰亚胺、方酸菁、喹啉、联萘酚等不同荧光分子的分子受体，对NSAIDs检测具有高选择性和灵敏度。同时，包括CdSe/ZnS、Cd/S量子点（QDs）、含碳点的印迹聚合物、Ag和Au纳米颗粒（NPs）、水凝胶包埋化学传感器在内的纳米结构组件也被用于NSAIDs检测。本综述强调了结合分子识别元件和纳米材料，通过各种光物理性质的变化实现不同的结合途径，以开发能够快速、灵敏和选择性检测NSAIDs的创新传感器。该综述还基于已报道的设计受体和纳米结构组件，讨论了该领域当前的挑战和未来前景。据我们所知，目前尚未有关于该主题的综述报道。因此，本综述将有效地指导研究人员设计各种新型分子受体和纳米结构材料来检测NSAIDs。
