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使用零维碳纳米结构材料进行过氧化氢定量分析:综述

Hydrogen Peroxide Quantification Using Zero Dimensional Carbon Nanostructured Materials: A Review.

作者信息

Sharma Priti, Nangare Sopan N, Bagade Shashikant B, Sonawane Sandeep S, Patil Dipak D

机构信息

Department of Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.

Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.

出版信息

Crit Rev Anal Chem. 2024 Dec 2:1-21. doi: 10.1080/10408347.2024.2427130.

Abstract

Hydrogen peroxide (HO) is suspected to promote cancer. Higher concentrations of HO have always harmed mammalian cells, other living things, as well as the environment. As well, elevated concentrations of HO might cause major health problems such as cancer, cardiovascular disease, asthma, Alzheimer's disease, etc. As all, bioanalysis, environmental protection, and food security are needed for the rapid and accurate sensing of HO. For the sensing of HO, nanoparticle construction of carbon-based sensors has been used. Zero-dimensional (0D) nanostructures or nanosized designs of carbon-based fluorescent probes such as graphene quantum dots (GQDs) and carbon quantum dots (CQDs/CDs) are gaining popularity in sensing. Therefore, this review focused on current developments in sensing systems made possible by innovative applications of GQDs with CQDs, with a focus on how these materials significantly enhance overall HO detection. In brief, the review article focuses on the basic insights of HO and carbon-based nanomaterials. After this, the use of GQDs and CQDs-based sensors for HO detection is discussed in a brief period from 2015 to 2024. At last, the current challenges, future prospects, and concluding remarks have been added. As an outcome, GQDs and CQDs showed the potential for sensing HO because of their distinctive electrical, fluorescent, photoluminescent, chemiluminescent, and electrochemiluminescent features. Carbon-based sensors for the recognition of HO utilized a variety of methods, counting PET, IFF, static quenching, dynamic quenching, FRET, etc. As an outcome, it appears that carbon-based nanoscale sensors offered potential options for highly effective yet precise sensors for the detection of HO. In winding up, the GQDs and CQDs-based sensing nanosystems provide a new platform for the recognition of HO that can open an innovative era for the diagnosis of health issues as well as monitor several environmental processes and issues at the point of care.

摘要

过氧化氢(HO)被怀疑会促进癌症。较高浓度的HO一直对哺乳动物细胞、其他生物以及环境有害。此外,HO浓度升高可能会导致诸如癌症、心血管疾病、哮喘、阿尔茨海默病等重大健康问题。总之,为了快速准确地检测HO,需要进行生物分析、环境保护和食品安全方面的工作。为了检测HO,人们采用了基于碳的传感器的纳米颗粒构建方法。零维(0D)纳米结构或基于碳的荧光探针(如石墨烯量子点(GQDs)和碳量子点(CQDs/CDs))的纳米尺寸设计在传感领域越来越受欢迎。因此,本综述聚焦于通过GQDs与CQDs的创新应用实现的传感系统的当前发展,重点关注这些材料如何显著提高整体HO检测能力。简而言之,这篇综述文章聚焦于HO和基于碳的纳米材料的基本见解。在此之后,简要讨论了2015年至2024年期间基于GQDs和CQDs的传感器用于HO检测的情况。最后,增加了当前面临的挑战、未来前景以及总结性评论。结果表明,GQDs和CQDs因其独特的电学、荧光、光致发光、化学发光和电化学发光特性而具有检测HO的潜力。用于识别HO的基于碳的传感器采用了多种方法,包括PET、IFF、静态猝灭、动态猝灭、FRET等。结果表明,基于碳的纳米级传感器为高效且精确的HO检测传感器提供了潜在选择。总之,基于GQDs和CQDs的传感纳米系统为HO的识别提供了一个新平台,可为健康问题的诊断开创一个创新时代,并在护理点监测多个环境过程和问题。

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