Nairuz Tahsin, Kabir Yearul
Department of Biochemistry and Molecular Biology, Noakhali Science and Technology University, Noakhali, Bangladesh.
Department of Biomedical Engineering, Keimyung University, Daegu 42601, Republic of Korea.
J Cancer Epidemiol. 2024 Nov 20;2024:9194714. doi: 10.1155/jcep/9194714. eCollection 2024.
Glutathione S-transferases (GSTs) play a significant role in carcinogen detoxification, and hence, polymorphisms of this gene may lead to lung cancer susceptibility. Accordingly, this study is aimed at investigating GSTM1 and GSTT1 polymorphisms' association with lung cancer risk and their effects on the toxicities of platinum-based chemotherapy used to treat Bangladeshi lung cancer patients. The study subjects comprised 180 lung cancer patients and 200 healthy volunteers. Genetic polymorphisms of GSTM1 and GSTT1 were analyzed using a multiplex PCR-based method. Chemotherapy toxicity was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE v5.0). GSTM1 null genotype was found to be significantly associated with a 1.6-fold increased risk of lung cancer (OR = 1.60, 95%CI = 1.01-2.52, = 0.0491), whereas no significant association was observed with GSTT1 null genotype and combined GSTM1 and GSTT1 null genotype. Moreover, no significant relationship was observed between GSTM1 and GSTT1 polymorphisms and the increased risk of platinum-based chemotherapy-induced toxicities in lung cancer patients. These findings indicated that the GSTM1 null but not GSTT1 null genotype was significantly associated with lung cancer susceptibility. These polymorphisms were not related to platinum-based chemotherapy-induced toxicities in Bangladeshi lung cancer patients.
谷胱甘肽S-转移酶（GSTs）在致癌物解毒过程中发挥着重要作用，因此，该基因的多态性可能导致肺癌易感性。据此，本研究旨在调查GSTM1和GSTT1基因多态性与肺癌风险的关联，以及它们对用于治疗孟加拉国肺癌患者的铂类化疗毒性的影响。研究对象包括180例肺癌患者和200名健康志愿者。采用基于多重PCR的方法分析GSTM1和GSTT1的基因多态性。使用不良事件通用术语标准（CTCAE v5.0）评估化疗毒性。发现GSTM1无效基因型与肺癌风险增加1.6倍显著相关（OR = 1.60，95%CI = 1.01 - 2.52，P = 0.0491），而未观察到GSTT1无效基因型以及GSTM1和GSTT1联合无效基因型与肺癌风险有显著关联。此外，未观察到GSTM1和GSTT1基因多态性与肺癌患者铂类化疗诱导的毒性增加风险之间存在显著关系。这些发现表明，GSTM1无效基因型而非GSTT1无效基因型与肺癌易感性显著相关。这些多态性与孟加拉国肺癌患者铂类化疗诱导的毒性无关。
