Yang Haiyan, Yang Siyu, Liu Jing, Shao Fuye, Wang Haiyu, Wang Yadong
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
Sci Rep. 2015 Mar 23;5:9392. doi: 10.1038/srep09392.
Previous studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. However, the results remained controversial. The aim of this study was to clarify the association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population. Systematic searches were performed through the search engines of Medline/Pubmed, Web of Science, EMBASE, CNKI and Wanfang Medical Online. The pooled effects were calculated by STATA 10.0 software package and Review Manager 5.0.24. Overall, we observed an association of GSTM1 deletion polymorphism with increased lung cancer risk in Chinese population (odds ratio (OR) = 1.46, 95% confidence interval (95%CI): 1.32-1.66 for null genotype vs. present genotype) based on 53 studies including 7,833 cases and 10,353 controls. We also observed an increased risk of GSTM1 null genotype for lung cancer in stratified analyses by source of control, smoking status and histological type. The findings suggest that GSTM1 deletion polymorphism may contribute to lung cancer risk in Chinese population. Further, well-designed studies with larger sample sizes are required to verify the results.
既往研究报道了谷胱甘肽S-转移酶M1（GSTM1）基因缺失多态性与中国人群肺癌遗传易感性的关联。然而，结果仍存在争议。本研究的目的是阐明GSTM1基因缺失多态性与中国人群肺癌风险的关联。通过Medline/Pubmed、Web of Science、EMBASE、中国知网和万方医学在线等搜索引擎进行系统检索。采用STATA 10.0软件包和RevMan 5.0.24计算合并效应。总体而言，基于53项研究（包括7833例病例和10353例对照），我们观察到中国人群中GSTM1基因缺失多态性与肺癌风险增加相关（优势比（OR）=1.46，95%置信区间（95%CI）：无效基因型与现有基因型相比为1.32-1.66）。在按对照来源、吸烟状况和组织学类型进行的分层分析中，我们还观察到GSTM1无效基因型患肺癌的风险增加。研究结果表明，GSTM1基因缺失多态性可能与中国人群的肺癌风险有关。此外，需要设计更完善、样本量更大的研究来验证这些结果。
