纤维蛋白原、纤维蛋白降解产物和D-二聚体作为溃疡性结肠炎疾病严重程度的潜在生物标志物：一项回顾性研究
Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.
作者信息
Feng Wan, Zhu Lei, Zhao Song, Zheng Kai, Xu Luzhou, Shen Hong
机构信息
Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing, People's Republic of China.
出版信息
Int J Gen Med. 2024 Nov 26;17:5573-5579. doi: 10.2147/IJGM.S477285. eCollection 2024.
PURPOSE
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC.
PATIENTS AND METHODS
A total of 364 UC patients were analyzed with 163 female and 201 male. Disease activity was determined according to the Truelove and Witts criteria. The fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated.
RESULTS
We found higher D-dimer, FDP, FIB levels in severe UC compared with non-severe patients.The area under the curve (AUC) of D-dimer was 0.852 (95% CI 0.805 to 0.898) and the optimum cut-off point was 0.585, with a sensitivity of 80.6% and a specificity of 78.9%. Furthermore, D-dimer and FIB are positively correlated with ESR and CRP levels.
CONCLUSION
Our results indicate that D-dimer, FDP, and FIB levels are potential biomarkers for disease severity in UC patients.
目的
溃疡性结肠炎（UC）是一种主要影响大肠的特发性慢性炎症性疾病。在UC患者中已检测到凝血异常。本研究旨在评估UC患者的凝血相关参数。
患者与方法
共分析了364例UC患者，其中女性163例，男性201例。根据Truelove和Witts标准确定疾病活动度。评估纤维蛋白原（FIB）、D-二聚体、纤维蛋白/纤维蛋白原降解产物（FDP）、C反应蛋白（CRP）和红细胞沉降率（ESR）水平。
结果
我们发现重度UC患者的D-二聚体、FDP、FIB水平高于非重度患者。D-二聚体的曲线下面积（AUC）为0.852（95%CI 0.805至0.898），最佳截断点为0.585，敏感性为80.6%，特异性为78.9%。此外，D-二聚体和FIB与ESR和CRP水平呈正相关。
结论
我们的结果表明，D-二聚体、FDP和FIB水平是UC患者疾病严重程度的潜在生物标志物。
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