儿童急性淋巴细胞白血病中采用白消安、氟达拉滨和依托泊苷靶向预处理方案进行异基因造血干细胞移植的前瞻性II期研究 - Suppr

Prospective phase II study of allogeneic hematopoietic stem cell transplantation with targeted busulfan, fludarabine, and etoposide conditioning in pediatric acute lymphoblastic leukemia.

作者信息

Hong Kyung Taek, Park Hyun Jin, Kim Bo Kyung, Choi Jung Yoon, Song Sang Hoon, Lee SeungHwan, Yu Kyung-Sang, Jang In-Jin, Kang Hyoung Jin

机构信息

Department of Pediatrics Seoul National University College of Medicine, Seoul National University Children's Hospital Seoul Republic of Korea.

Seoul National University Cancer Research Institute Seoul Republic of Korea.

出版信息

Hemasphere. 2024 Nov 28;8(12):e70051. doi: 10.1002/hem3.70051. eCollection 2024 Dec.

DOI:10.1002/hem3.70051

PMID:39619243

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11604129/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0597/11604129/01863273a9fd/HEM3-8-e70051-g001.jpg

相似文献

Prospective phase II study of allogeneic hematopoietic stem cell transplantation with targeted busulfan, fludarabine, and etoposide conditioning in pediatric acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中采用白消安、氟达拉滨和依托泊苷靶向预处理方案进行异基因造血干细胞移植的前瞻性II期研究

Hemasphere. 2024 Nov 28;8(12):e70051. doi: 10.1002/hem3.70051. eCollection 2024 Dec.

Favorable outcome of hematopoietic stem cell transplantation using a targeted once-daily intravenous busulfan-fludarabine-etoposide regimen in pediatric and infant acute lymphoblastic leukemia patients.在儿童和婴幼儿急性淋巴细胞白血病患者中，使用靶向每日一次静脉注射白消安-氟达拉滨-依托泊苷方案进行造血干细胞移植的良好结果。

Biol Blood Marrow Transplant. 2015 Jan;21(1):190-5. doi: 10.1016/j.bbmt.2014.09.013. Epub 2014 Sep 22.

Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia.降低强度预处理方案联合白消安和氟达拉滨用于急性淋巴细胞白血病的异基因造血干细胞移植。

Yonsei Med J. 2020 Jun;61(6):452-459. doi: 10.3349/ymj.2020.61.6.452.

Busulfan with 400 centigray of total body irradiation and higher dose fludarabine: An alternative regimen for hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia.全身照射 400 厘戈瑞联合更高剂量氟达拉滨的白消安：儿科急性淋巴细胞白血病造血干细胞移植的替代方案。

Pediatr Blood Cancer. 2024 Apr;71(4):e30844. doi: 10.1002/pbc.30844. Epub 2024 Jan 12.

Vorinostat Combined with Busulfan, Fludarabine, and Clofarabine Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Leukemia: Long-Term Study Outcomes.伏立诺他联合白消安、氟达拉滨和克拉屈滨预处理方案用于急性白血病患者异基因造血干细胞移植：长期研究结果。

Transplant Cell Ther. 2022 Aug;28(8):501.e1-501.e7. doi: 10.1016/j.jtct.2022.05.021. Epub 2022 May 23.

Comparison of Conditioning with Fludarabine/Busulfan and Fludarabine/Melphalan in Allogeneic Transplantation Recipients 50 Years or Older.50 岁及以上异基因移植受者中氟达拉滨/白消安与氟达拉滨/马法兰预处理方案的比较。

Biol Blood Marrow Transplant. 2017 Dec;23(12):2079-2087. doi: 10.1016/j.bbmt.2017.09.003. Epub 2017 Sep 7.

Busulfan plus fludarabine as a myeloablative conditioning regimen compared with busulfan plus cyclophosphamide for acute myeloid leukemia in first complete remission undergoing allogeneic hematopoietic stem cell transplantation: a prospective and multicenter study.在接受异基因造血干细胞移植的首次完全缓解的急性髓系白血病患者中，与白消安加环磷酰胺相比，白消安加氟达拉滨作为清髓性预处理方案：一项前瞻性多中心研究。

J Hematol Oncol. 2013 Feb 8;6:15. doi: 10.1186/1756-8722-6-15.

Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL.基于全身照射与基于化疗的预处理方案对儿童急性淋巴细胞白血病异基因造血干细胞移植早期并发症的比较

J Pediatr Hematol Oncol. 2021 Oct 1;43(7):266-270. doi: 10.1097/MPH.0000000000002055.

Busulfan and fludarabine conditioning regimen given at hematological nadir of cytoreduction fludarabine, cytarabine, and idarubicin chemotherapy in patients with refractory acute myeloid leukemia undergoing allogeneic stem cell transplantation: a single arm pilot consort study.在接受异基因干细胞移植的难治性急性髓系白血病患者中，在氟达拉滨、阿糖胞苷和伊达比星化疗导致的血液学最低点给予白消安和氟达拉滨预处理方案：一项单臂前瞻性队列研究。

Medicine (Baltimore). 2015 Apr;94(15):e706. doi: 10.1097/MD.0000000000000706.

Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial.对于老年急性髓系白血病或骨髓增生异常综合征患者，在异基因造血干细胞移植前采用曲奥舒凡或白消安加氟达拉滨作为预处理方案（MC-FludT.14/L）：一项随机、非劣效性3期试验。

Lancet Haematol. 2020 Jan;7(1):e28-e39. doi: 10.1016/S2352-3026(19)30157-7. Epub 2019 Oct 9.

引用本文的文献

Comparable outcomes for pediatric acute lymphoblastic leukemia patients receiving conditioning with total body irradiation or chemotherapy: A nationwide, Korean registry-based study.接受全身照射或化疗预处理的儿童急性淋巴细胞白血病患者的可比结局：一项基于韩国全国登记处的研究。

Hemasphere. 2025 Jun 17;9(6):e70158. doi: 10.1002/hem3.70158. eCollection 2025 Jun.

本文引用的文献

A comprehensive comparison between TBI vs non-TBI-based conditioning regimen in pediatric patients with acute lymphoblastic leukemia: A systematic review and meta-analysis.儿童急性淋巴细胞白血病中 TBI 与非 TBI 为基础的预处理方案的全面比较：系统评价和荟萃分析。

Leuk Res. 2023 Dec;135:107416. doi: 10.1016/j.leukres.2023.107416. Epub 2023 Oct 28.

Low rate of nonrelapse mortality in under-4-year-olds with ALL given chemotherapeutic conditioning for HSCT: a phase 3 FORUM study.年龄<4 岁的 ALL 患儿接受 HSCT 前化疗预处理后非复发死亡率低：一项 FORUM 研究的 3 期临床试验

Blood Adv. 2024 Jan 23;8(2):416-428. doi: 10.1182/bloodadvances.2023010591.

Prognostic impact of total body irradiation dose in pediatric acute lymphoblastic leukemia patients treated with allogeneic hematopoietic stem cell transplantation in second complete remission.第二次完全缓解期接受异基因造血干细胞移植治疗的儿童急性淋巴细胞白血病患者全身照射剂量的预后影响

Blood Res. 2022 Dec 31;57(4):256-263. doi: 10.5045/br.2022.2022174. Epub 2022 Dec 20.

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.基于全身照射的异基因 HSCT 后儿童 ALL 后续恶性肿瘤的发生率 - 前瞻性 ALL-SCT 2003 试验的长期随访。

Leukemia. 2022 Nov;36(11):2567-2576. doi: 10.1038/s41375-022-01693-z. Epub 2022 Sep 12.

Post-Transplantation Cyclophosphamide-Based Haploidentical versus Matched Unrelated Donor Peripheral Blood Hematopoietic Stem Cell Transplantation Using Myeloablative Targeted Busulfan-Based Conditioning for Pediatric Acute Leukemia.同种异体移植后基于环磷酰胺的单倍体与匹配的无关供者外周血造血干细胞移植，采用含靶向美法仑的清髓性预处理方案治疗儿科急性白血病。

Transplant Cell Ther. 2022 Apr;28(4):195.e1-195.e7. doi: 10.1016/j.jtct.2022.01.002. Epub 2022 Jan 10.

Impact of Total Body Irradiation-Based Myeloablative Conditioning Regimens in Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analysis.基于全身照射的清髓性预处理方案在接受异基因造血干细胞移植的急性淋巴细胞白血病患者中的影响：系统评价和荟萃分析。

Transplant Cell Ther. 2021 Jul;27(7):620.e1-620.e9. doi: 10.1016/j.jtct.2021.03.026. Epub 2021 Mar 30.

Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.儿童 ALL 中全身放疗或化疗预处理：一项多国、随机、非劣效性 III 期研究。

J Clin Oncol. 2021 Feb 1;39(4):295-307. doi: 10.1200/JCO.20.02529. Epub 2020 Dec 17.

Occurrence of long-term effects after hematopoietic stem cell transplantation in children affected by acute leukemia receiving either busulfan or total body irradiation: results of an AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) retrospective study.儿童急性白血病患者接受白消安或全身照射造血干细胞移植后长期效应的发生：AIEOP（意大利儿科血液学肿瘤学会）回顾性研究的结果。

Bone Marrow Transplant. 2020 Oct;55(10):1918-1927. doi: 10.1038/s41409-020-0806-8. Epub 2020 Jan 29.

Low burden of minimal residual disease prior to transplantation in children with very high risk acute lymphoblastic leukaemia: The NOPHO ALL2008 experience.极低危急性淋巴细胞白血病患儿移植前微小残留病低负担：NOPHO ALL2008 经验。

Br J Haematol. 2019 Mar;184(6):982-993. doi: 10.1111/bjh.15761. Epub 2019 Jan 24.

Favorable Outcome of Post-Transplantation Cyclophosphamide Haploidentical Peripheral Blood Stem Cell Transplantation with Targeted Busulfan-Based Myeloablative Conditioning Using Intensive Pharmacokinetic Monitoring in Pediatric Patients.在儿科患者中，通过强化药代动力学监测，使用靶向基于白消安的清髓性预处理方案，行移植后环磷酰胺单倍体外周血造血干细胞移植，可获得良好结局。

Biol Blood Marrow Transplant. 2018 Nov;24(11):2239-2244. doi: 10.1016/j.bbmt.2018.06.034. Epub 2018 Jul 6.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Prospective phase II study of allogeneic hematopoietic stem cell transplantation with targeted busulfan, fludarabine, and etoposide conditioning in pediatric acute lymphoblastic leukemia.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献