Mackels Laurane, Aktan David, Depierreux Frédérique
Neurology Department, Regional Hospital of Liege, Liege, Belgium.
Neurology Department, University Hospital of Liege, Liege, Belgium.
Tremor Other Hyperkinet Mov (N Y). 2024 Nov 25;14:58. doi: 10.5334/tohm.946. eCollection 2024.
While levodopa may benefit some patients with monogenic Parkinson's Disease and parkinsonism, others may exhibit aberrant responses earlier after exposure. Reporting treatment responses in rare genetic parkinsonism will help tailor therapeutic approaches to specific patients subpopulations.
We report the therapeutic response in a patient with X-linked parkinsonism, who exhibited motor and non-motor complications within a few months of Levodopa.
Severe and debilitating Levodopa-induced complications can occur very early in the treatment course of X-linked parkinsonism, highlighting the need for an individualized therapeutic approach and follow-up in rare parkinsonian syndromes.
虽然左旋多巴可能使一些单基因帕金森病和帕金森综合征患者受益，但其他患者在接触后可能更早出现异常反应。报告罕见遗传性帕金森综合征的治疗反应将有助于为特定患者亚群量身定制治疗方法。
我们报告了一名X连锁帕金森综合征患者的治疗反应，该患者在使用左旋多巴几个月内出现了运动和非运动并发症。
严重且使人衰弱的左旋多巴诱导的并发症可能在X连锁帕金森综合征的治疗过程中很早就出现，这突出了在罕见帕金森综合征中采用个体化治疗方法和随访的必要性。
