Arpaci Nazile, Ak Mehmet, Uguz Faruk, Kurban Sevil, Kulaksizoglu Sevsen
Department of Psychiatry, Konya Training and Research Hospital, Konya, Turkey.
Department of Psychiatry, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.
Psychiatry Clin Psychopharmacol. 2021 Mar 1;31(1):1-8. doi: 10.5152/pcp.2021.20080. eCollection 2021 Mar.
This study aimed to examine the role of central and peripheral neuropeptides in olanzapine-induced weight gain and metabolic changes.
Thirty patients who would receive olanzapine treatment were evaluated at the beginning of the treatment at the 2 and 8 weeks. Weight, waist circumference, the central neuropeptides pro-opiomelanocortin (POMC) and neuropeptide Y (NPY), and the peripheral adipokine leptin and the peripheral peptide cholecystokinin (CCK) levels were measured in each control. In addition, biochemical parameters such as fasting blood glucose (FBG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total and direct bilirubin, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, and triglyceride (TG) were measured.
There were statistically significant differences weight and waist circumference levels compared to the initial levels. As observed in previous studies in the literature, changes in biochemical parameters including AST, ALT, total and direct bilirubin, LDL, TG, total cholesterol, and HDL levels were statistically significant. Levels of the neuropeptides POMC and NPY tended to increase at early stages and decrease at later stages of the treatment, while CCK and leptin levels kept increasing throughout the treatment period. The changes in POMC and CCK levels were statistically significant.
The results suggest that POMC and CCK may play a role in olanzapine-related weight gain.
本研究旨在探讨中枢和外周神经肽在奥氮平所致体重增加及代谢变化中的作用。
对30例即将接受奥氮平治疗的患者在治疗开始时、治疗2周和8周时进行评估。测量每位对照者的体重、腰围、中枢神经肽阿黑皮素原（POMC）和神经肽Y（NPY），以及外周脂肪因子瘦素和外周肽胆囊收缩素（CCK）水平。此外，还测量了生化参数，如空腹血糖（FBG）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）、碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）、总胆红素和直接胆红素、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇和甘油三酯（TG）。
与初始水平相比，体重和腰围水平存在统计学显著差异。正如文献中先前研究观察到的，包括AST、ALT、总胆红素和直接胆红素、LDL、TG、总胆固醇和HDL水平在内的生化参数变化具有统计学显著性。神经肽POMC和NPY水平在治疗早期趋于升高而在后期降低，而CCK和瘦素水平在整个治疗期间持续升高。POMC和CCK水平的变化具有统计学显著性。
结果表明POMC和CCK可能在奥氮平相关体重增加中起作用。
