Liu Yang, Wu Yuchuan, Shi Xiaolu, Tian Ye, Zhai Shaobo, Yang Zheng, Chu Shunli
Department of Implantology, Hospital of Stomatology, Jilin University, Changchun, China.
Front Pharmacol. 2024 Nov 15;15:1420613. doi: 10.3389/fphar.2024.1420613. eCollection 2024.
Lead is persistent in the environment as a toxic substance and accumulates in the human body. Lead exposure has far-reaching harmful effects on all human systems and is widely recognized as a health and public health concern. Lead exposure poses a significant risk to oral health, as it destroys salivary glands and alveolar bone. It also induces oxidative stress which results in an immune response. Lead exposure appears to adversely affect periodontal tissues. Currently, the available evidence on the relationship between blood lead and periodontitis is insufficient and further research is necessary.
In this study, the objectives were to clarify the association between blood lead and periodontitis, as well as to explore potential dose-response relationships between blood lead exposure and periodontitis, as well as to determine appropriate thresholds for the effects of blood lead on periodontitis.
We conducted a cross-sectional study involving 8,550 participants with American adults aged 30 or older. blood Lead, periodontitis, age, sex, race, heart rate, education level, poverty index, marital status, body mass index, smoking status, alcohol drinking status, hypertension, diabetes and stroke. were collected from participants. Logistic regression, smooth curve fittingwere utilized to substantiate the research objectives.
There were a total of 8,550 participants of which 52.2% (4,467/8,550) had moderate/severe periodontitis. Compared with Q1 (0.15-0.93 ug/L), where blood lead levels were lower, the OR values for adjusted blood lead and periodontitis in Q2 (0.93-1.60 ug/L) and Q3 (1.60-61.29 ug/L) were 1.18 (95% CI: 1.12-1.25, < 0.001) and 1.43 (95% CI: 1.34-1.52, < 0.001). The association between blood lead levels and periodontitis exhibited a curve (non-linear, < 0.001), with an inflection point of roughly 2.700 ug/L. The OR values for moderate/severe periodontitis in participants with blood lead levels <2.700ug/L was 1.318 (95% CI: 1.193-1.457, < 0.001).
Blood lead levels are positively associated with periodontitis. Blood lead levels increased by five units and were associated with an increase in moderate and severe periodontitis risk by 36%. There is a curvilinear relationship between blood lead and periodontitis with a threshold effect and an inflection point of approximately 2.7 ug/L.
铅作为一种有毒物质在环境中持久存在，并在人体中蓄积。铅暴露对人体所有系统都有深远的有害影响，被广泛认为是一个健康和公共卫生问题。铅暴露对口腔健康构成重大风险，因为它会破坏唾液腺和牙槽骨。它还会引发氧化应激，从而导致免疫反应。铅暴露似乎会对牙周组织产生不利影响。目前，关于血铅与牙周炎之间关系的现有证据不足，有必要进行进一步研究。
在本研究中，目的是阐明血铅与牙周炎之间的关联，探索血铅暴露与牙周炎之间潜在的剂量反应关系，并确定血铅对牙周炎影响的合适阈值。
我们进行了一项横断面研究，纳入了8550名30岁及以上的美国成年人参与者。收集了参与者的血铅、牙周炎、年龄、性别、种族、心率、教育水平、贫困指数、婚姻状况、体重指数、吸烟状况、饮酒状况、高血压、糖尿病和中风情况。采用逻辑回归、平滑曲线拟合来证实研究目的。
共有8550名参与者，其中52.2%（4467/8550）患有中度/重度牙周炎。与血铅水平较低的第一四分位数（0.15 - 0.93微克/升）相比，第二四分位数（0.93 - 1.60微克/升）和第三四分位数（1.60 - 61.29微克/升）中调整后的血铅与牙周炎的OR值分别为1.18（95%CI：1.12 - 1.25，<0.001）和1.43（95%CI：1.34 - 1.52，<0.001）。血铅水平与牙周炎之间的关联呈现曲线关系（非线性，<0.001），拐点约为2.700微克/升。血铅水平<2.700微克/升的参与者中，中度/重度牙周炎的OR值为1.318（95%CI：1.193 - 1.457，<0.001）。
血铅水平与牙周炎呈正相关。血铅水平每增加5个单位，中度和重度牙周炎风险增加36%。血铅与牙周炎之间存在曲线关系，具有阈值效应，拐点约为2.7微克/升。
