活性氧凝胶对MRONJ临床参数的影响。
Effect of active oxygen gel on the clinical parameters of MRONJ.
作者信息
Cristina de Cristo Bruna, Yousef Saleh Hassan, Weiss Suyany, Sebastiani Aline, Elsalanty Mohammed, Scariot Rafaela, Miranda Deliberador Tatiana
机构信息
Universidade Positivo, Curitiba, Brazil.
Latin American Institute of Dental Research and Education- ILAPEO, Curitiba, Brazil.
出版信息
Saudi Dent J. 2024 Nov;36(11):1456-1458. doi: 10.1016/j.sdentj.2024.09.003. Epub 2024 Sep 3.
PURPOSE
The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ.
METHODS
Using split-mouth study design, twelve rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / kg body weight in PBS) for 8 weeks. Then, the animals underwent surgery to remove the first and second right and left mandibular molars to induce osteonecrosis. The animals received topical application of oxygen gel (blue®m) on the right-side extraction site (Group T) 3 times a week until euthanasia after 6 weeks, with no intervention on the left side (Group C). The clinical parameters analyzed included the presence and dimension of bone exposure, suppuration and epithelialization.
RESULTS
Statistical analysis using chi-square and Mann-Whitney test (p value < 0.05) demonstrated that group C had more severe signs of MRONJ at euthanasia than in the group T.
CONCLUSION
Within the limitations of this pilot study, we can conclude that the application of active oxygen gel could be beneficial in the prevention of MRONJ.
目的
本研究旨在评估含活性氧凝胶预防下颌骨放射性骨坏死（MRONJ）的有效性。
方法
采用双盲研究设计，选用12只大鼠，其中雌性6只，雄性6只。所有大鼠每周静脉注射唑来膦酸（80μg/kg体重，溶于磷酸盐缓冲液），持续8周。然后，对动物进行手术，拔除左右下颌第一和第二磨牙以诱导骨坏死。右侧拔牙部位（T组）每周3次局部应用氧凝胶（blue®m），直至6周后安乐死，左侧不做干预（C组）。分析的临床参数包括骨暴露的存在和范围、化脓和上皮形成情况。
结果
采用卡方检验和曼-惠特尼检验进行统计分析（p值<0.05），结果显示安乐死时C组的MRONJ体征比T组更严重。
结论
在本初步研究的局限性范围内，我们可以得出结论，应用活性氧凝胶可能有助于预防MRONJ。
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