Pouraee Haniyeh, Asgharpour Masoumeh, Gholinia Hemmat, Ebrahimpour Soheil, Babazadeh Arefeh
Babol University of Medical Sciences, babol, Iran.
Department of Internal Medicine, Babol University of Medical Sciences, babol, Iran.
Caspian J Intern Med. 2024 Oct 19;16(1):96-105. doi: 10.22088/cjim.16.1.96. eCollection 2025 Winter.
The COVID-19 pandemic significantly threatens immunocompromised patients. We aimed to investigate the clinical and paraclinical findings and consequences of COVID-19 in kidney transplantation recipients.
In this retrospective study, kidney transplant recipients admitted to Ayatollah Rouhani, Shahid Beheshti, and Shahid Yahyanejad referral hospitals of Babol, North of Iran, with a diagnosis of COVID-19, were examined. Information such as demographic and laboratory findings, clinical symptoms, and treatments received was entered into pre-prepared questionnaires.
Out of the 35 patients included in the study, 19 (54.3%) were males, and 16 (45.7%) were females. The mean age of patients was 47.46 11.28. Among the clinical symptoms, cough and decreased level of consciousness were associated with a higher mortality rate (P= 0.02). Furthermore, the mortality rate was found to be 17.1%. C-reactive protein (CRP) level, oxygen saturation percentage, and diffuse lung involvement were significantly associated with COVID-19 mortality (p <0.05). In this study, no correlation was found between the amount of Cr and the outcome of COVID-19 disease (P = 0.66), and also, no significant relationship was found between the amount of BUN and the outcome of COVID-19 (P = 0.46). Even the patient who was admitted with a Cr of 6.4 did not die and was discharged with a Cr of 3.4.
Due to the higher mortality rate in transplant patients with COVID-19, the need for more clinically severe treatment and intensification of care in this group of patients is essential.
新型冠状病毒肺炎（COVID-19）大流行对免疫功能低下的患者构成了重大威胁。我们旨在调查肾移植受者感染COVID-19的临床和辅助检查结果及后果。
在这项回顾性研究中，对伊朗北部巴博勒的阿亚图拉·鲁哈尼、沙希德·贝赫什提和沙希德·亚亚内贾德转诊医院收治的确诊为COVID-19的肾移植受者进行了检查。将人口统计学和实验室检查结果、临床症状以及接受的治疗等信息录入预先准备好的问卷中。
纳入研究的35例患者中，男性19例（54.3%），女性16例（45.7%）。患者的平均年龄为47.46±11.28岁。在临床症状中，咳嗽和意识水平下降与较高的死亡率相关（P = 0.02）。此外，死亡率为17.1%。C反应蛋白（CRP）水平、血氧饱和度百分比和弥漫性肺部受累与COVID-19死亡率显著相关（p<0.05）。在本研究中，未发现肌酐水平与COVID-19疾病结局之间存在相关性（P = 0.66），并且，也未发现血尿素氮水平与COVID-19结局之间存在显著关系（P = 0.46）。即使是肌酐水平为6.4入院的患者也未死亡，出院时肌酐水平为3.4。
由于COVID-19移植患者的死亡率较高，对这组患者进行更严格的临床治疗和加强护理至关重要。
