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菊粉不影响高脂饮食联合胆碱和左旋肉碱的小鼠体内氧化三甲胺的形成。

Inulin does not affect trimethylamine N-oxide formation in mice with a high-fat diet combined with choline and L-carnitine.

作者信息

Wang Xin, Hu Xiaoyi, He Weiwei, Yin Jun-Yi

机构信息

State Key Laboratory of Food Science and Resources, China-Canada Joint Laboratory of Food Science and Technology (Nanchang) Nanchang University Nanchang China.

出版信息

Food Sci Nutr. 2024 Sep 15;12(11):8968-8977. doi: 10.1002/fsn3.4420. eCollection 2024 Nov.

DOI:10.1002/fsn3.4420
PMID:39619951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11606906/
Abstract

Emerging evidence suggests that gut bacteria-derived trimethylamine N-oxide (TMAO) elevates the risk of cardiovascular disease, and dietary fiber holds the potential to attenuate TMAO formation. However, the effectiveness of dietary fiber, such as inulin, in inhibiting TMAO formation remains controversial. Therefore, this study investigated the effect of inulin supplementation on TMAO formation in mice with high TMAO levels induced by a high-fat diet (HFD) combined with choline and L-carnitine. Results showed that HFD treatment significantly elevated blood TMAO concentrations and increased the abundances of TMAO formation-associated gut bacteria, as well as the abundances of functional genes responsible for TMA formation. While the supplementation of choline and L-carnitine greatly enhanced blood trimethylamine (TMA) and TMAO levels, inulin supplementation did not significantly affect TMAO levels and had limited impact on TMA-associated gut bacteria, except for .

摘要

新出现的证据表明，肠道细菌衍生的氧化三甲胺（TMAO）会增加心血管疾病风险，膳食纤维有可能减弱TMAO的形成。然而，膳食纤维（如菊粉）抑制TMAO形成的有效性仍存在争议。因此，本研究调查了补充菊粉对高脂饮食（HFD）联合胆碱和左旋肉碱诱导的高TMAO水平小鼠中TMAO形成的影响。结果表明，HFD处理显著提高了血液中TMAO浓度，增加了与TMAO形成相关的肠道细菌丰度，以及负责TMA形成的功能基因丰度。虽然补充胆碱和左旋肉碱极大地提高了血液中三甲胺（TMA）和TMAO水平，但补充菊粉对TMAO水平没有显著影响，对与TMA相关的肠道细菌影响有限，除了……

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/bfaee4cbdcad/FSN3-12-8968-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/4cae613340e9/FSN3-12-8968-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/3a154af19751/FSN3-12-8968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/b0fabb9b20f1/FSN3-12-8968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/a2d61034c157/FSN3-12-8968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/77aac9857ccd/FSN3-12-8968-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/bfaee4cbdcad/FSN3-12-8968-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/4cae613340e9/FSN3-12-8968-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/3a154af19751/FSN3-12-8968-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/b0fabb9b20f1/FSN3-12-8968-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/a2d61034c157/FSN3-12-8968-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/77aac9857ccd/FSN3-12-8968-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c8a/11606906/bfaee4cbdcad/FSN3-12-8968-g007.jpg

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