Wang Daosong, Xie Jiayi, Zhao Meng
RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Blood Sci. 2024 Nov 28;6(4):e00212. doi: 10.1097/BS9.0000000000000212. eCollection 2024 Oct.
Megakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform diverse functions in various physiological and pathological contexts. This comprehensive review highlights the functional diversity of MKs beyond thrombopoiesis, including their roles in regulating hematopoietic stem cells, modulating immune responses, contributing to hematological malignancies, and influencing aging processes.
巨核细胞（MKs）在骨髓细胞中占比小，主要负责产生血小板，而血小板对止血和伤口愈合至关重要。最近的研究表明，巨核细胞和血小板在各种生理和病理环境中发挥着多种功能。这篇综述强调了巨核细胞在血小板生成之外的功能多样性，包括它们在调节造血干细胞、调节免疫反应、导致血液系统恶性肿瘤以及影响衰老过程中的作用。
