Department of Infectious Diseases and Immunity, Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Canada (F.P., A.L., E.B.).
Centre de Recherche ARThrite, Faculté de Médecine de l'Université Laval, Québec, Canada (F.P., A.L., E.B.).
Arterioscler Thromb Vasc Biol. 2023 Nov;43(11):2088-2098. doi: 10.1161/ATVBAHA.123.318782. Epub 2023 Sep 7.
Megakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation. However, the localization of megakaryocytes in the lungs and the contribution of lung megakaryocytes to the general platelet pool has only recently been appreciated. Moreover, the conception of megakaryocytes as uniform cells with the sole purpose of platelet production has been challenged. Here, we review the literature on megakaryocyte cell identity and location with a special focus on recent observations of megakaryocyte subpopulations identified by transcriptomic analyses.
巨核细胞通常被称为大型、多倍体的骨髓常驻细胞，通过生成血小板来促进止血。在 19 世纪发现巨核细胞后不久，人们就在骨髓以外的组织位置描述了巨核细胞，特别是在肺部和血液循环中。然而，巨核细胞在肺部的定位以及肺巨核细胞对一般血小板池的贡献直到最近才被认识到。此外，巨核细胞作为具有唯一生成血小板目的的均匀细胞的概念也受到了挑战。在这里，我们回顾了关于巨核细胞细胞特性和位置的文献，特别关注了最近通过转录组分析鉴定的巨核细胞亚群的观察结果。
