Jahankir Mohamed Jameer Basha, Ramesh Harisharan, Chakaravarthi Thilak, Agarwal Ajay, Goyal Amit, Balachander Gowri Manohari
Caldor Health Technologies Pvt Ltd, Mannudaiyar Street, Kurumbapalayam, Coimbatore, Tamil Nadu - 641007, India.
Atal Incubation Centre - Centre for Cellular and Molecular Biology, IDA Uppal, Habsiguda, Hyderabad, Telangana - 500039, India.
J Mater Chem B. 2025 Jan 2;13(2):668-682. doi: 10.1039/d4tb01306a.
Deviated nasal septum (DNS) is a common condition affecting nasal breathing, which is generally treated using septoplasty. However, this invasive surgical method carries potential risks of post-surgical complications. Alternatively, electromechanical reshaping (EMR) is a novel method that has evolved as a non-thermal, minimally invasive option to reshape the cartilage using mechanical pressure and direct current (DC) without significant tissue damage. However, the existing flat and needle electrodes tested in animal tissues have raised significant concerns due to their safety. Thus, herein, we aimed to develop a novel strip electrode configuration and optimize dosimetry to achieve efficient reshaping without compromising its safety. Electric field simulations showed that our novel 5-strip electrode configuration with a thickness of 0.5 mm achieved optimal electric field, requiring minimal current flow compared to flat electrodes. EMR was performed on goat cartilage at various dosimetry groups to analyze four-day shape retention. The optimized strip electrode reshaped the goat septal cartilage effectively at a dosimetry of 20 mA for 15 minutes, whereas the flat electrode needed 35 mA for 15 minutes. DMMB assay, ATR-FTIR spectroscopy, tensile testing, and histopathology analysis demonstrated reduced tissue damage while supporting increased efficiency and mechanical stability with the strip electrode configuration, emphasizing its safety. Thus, the optimized strip electrode-based EMR emerges as a viable non-invasive approach for reshaping the nasal septal cartilage, which can be used to treat DNS. Further studies are recommended to validate the long-term safety and efficacy of this technique.
鼻中隔偏曲（DNS）是一种影响鼻腔呼吸的常见病症，通常采用鼻中隔成形术进行治疗。然而，这种侵入性手术方法存在术后并发症的潜在风险。另外，机电重塑（EMR）是一种新型方法，已发展成为一种非热、微创的选择，可利用机械压力和直流电（DC）重塑软骨，且不会造成明显的组织损伤。然而，在动物组织中测试的现有扁平电极和针状电极因其安全性引发了重大担忧。因此，在本文中，我们旨在开发一种新型带状电极配置并优化剂量测定，以在不影响其安全性的情况下实现高效重塑。电场模拟表明，我们厚度为0.5毫米的新型五带状电极配置实现了最佳电场，与扁平电极相比，所需电流最小。在不同剂量测定组的山羊软骨上进行EMR，以分析四天后的形状保持情况。优化后的带状电极在20毫安的剂量下作用15分钟即可有效地重塑山羊鼻中隔软骨，而扁平电极则需要35毫安作用15分钟。DMMB分析、ATR-FTIR光谱分析、拉伸测试和组织病理学分析表明，带状电极配置在支持提高效率和机械稳定性的同时减少了组织损伤，强调了其安全性。因此，基于优化带状电极的EMR成为一种可行的鼻中隔软骨重塑非侵入性方法，可用于治疗DNS。建议进一步研究以验证该技术的长期安全性和有效性。
