脂肪样基质癌相关成纤维细胞的消耗增强胰腺癌免疫治疗。
Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy.
作者信息
Rupert Joseph, Daquinag Alexes, Yu Yongmei, Dai Yulin, Zhao Zhongming, Kolonin Mikhail G
机构信息
Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Disease, McGovern Medical School, Houston, Texas.
Center for Precision Health, McWilliams School of Biomedical Informatics and School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, Texas.
出版信息
Cancer Res Commun. 2025 Jan 1;5(1):5-12. doi: 10.1158/2767-9764.CRC-24-0298.
This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.
这项研究表明，癌症相关成纤维细胞（CAFs）群体对胰腺癌进展具有不同影响，并表明清除表达脂肪标志物的CAFs可增强免疫检查点阻断的肿瘤/转移抑制作用。
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