[脊柱关节炎发病机制中的微生物和遗传因素]
[Microbial and genetic factors in the pathogenesis of spondyloarthritis].
作者信息
Rademacher Judith, Poddubnyy Denis, Rios Rodriguez Valeria
机构信息
Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, (including Nutrition Medicine), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland.
Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
出版信息
Z Rheumatol. 2025 May;84(4):268-275. doi: 10.1007/s00393-024-01593-w. Epub 2024 Dec 2.
Spondyloarthritis (SpA) is a heterogenous group of diseases with an yet unknown exact pathogenesis. An interplay between genetic predispositionw (mainly HLA-B*27 positivity), a barrier leakage (of skin and gut) and environmental influences, such as the contact to certain microbiota are suspected to lead to an activation of the immune system and through this to the development and maintenance of the disease.
脊柱关节炎（SpA）是一组病因尚未明确的异质性疾病。遗传易感性（主要是HLA - B*27阳性）、（皮肤和肠道的）屏障渗漏以及环境影响（如接触某些微生物群）之间的相互作用被怀疑会导致免疫系统激活，进而引发并维持该疾病。
Zotero 插件