Montgomery T D, Leid R W, Wescott R B
Vet Parasitol. 1986 Jan;19(1-2):55-65. doi: 10.1016/0304-4017(86)90032-4.
The host-parasite relationship of Fasciola hepatica in cattle was characterized by determining the effects of the parasite on the bovine complement system. Phosphosaline extracts of F. hepatica adults inhibited both the classical and alternative pathways of complement activation in normal bovine and human sera in a protein dose-dependent manner. The in vitro reaction of viable newly excysted juveniles (NEJ) with bovine serum (NBS) and with bovine serum containing antibodies specific to F. hepatica (IBS) resulted in no detectable changes in serum hemolytic complement activity for either pathway. This lack of complement consumption occurred even though these same flukes incubated in IBS for at least 24 h developed a precipitate that adhered to the parasite tegument, a feature that may reflect antibody--antigen reactions.
通过确定肝片吸虫对牛补体系统的影响，来表征其在牛体内的宿主-寄生虫关系。肝片吸虫成虫的磷酸盐水提取物以蛋白质剂量依赖性方式抑制正常牛血清和人血清中补体激活的经典途径和替代途径。存活的新脱囊幼虫（NEJ）与牛血清（NBS）以及含有针对肝片吸虫的特异性抗体的牛血清（IBS）的体外反应，导致两种途径的血清溶血补体活性均未检测到变化。即使这些相同的吸虫在IBS中孵育至少24小时后会形成附着在虫体表膜上的沉淀物，这一特征可能反映了抗体-抗原反应，但仍未出现补体消耗的情况。
